摘要
目的:研究胃癌患者的血脂和CA系列肿瘤标志物测定的临床应用。方法:采用生化法测定了89例胃癌患者的血脂水平,化学发光免疫分析了血清CA125、CA15-3和CA19-9水平,并与66例正常对照组进行了比较性分析。结果:89例胃癌患者的TC和HDL-C水平较之66例正常对照组明显降低(P均<0.05),并随胃癌患者的严重程度降低越来越明显(P>0.05～<0.01)。血清TG和LDL-C水平稍增高,但无明显差异(P均>0.05)。仅32例Ⅳ期胃癌的血清TG和LDL-C明显增高(P均<0.05)。89例胃癌患者的血清CA125、CA15-3和CA19-9水平较之66例正常对照组明显增高(P<0.05～<0.01),并随胃癌患者的严重程度而增高(P>0.05～<0.01)。结论:胃癌患者是血脂代谢紊乱的疾病,血清TC和HDL-C水平明显降低,而且胃癌患者越严重降低越明显。血清CA125、CA15-3和CA19-9诊断胃癌患者的阳性率较低,三指标的联检可弥补其不足。
Objective To study the clinical application in determining blood lipid and CA series tumor markers in patients with gastric carcinoma.Methods Blood lipid（with biochemistry） and serum CA125,CA15-3,CA19-9 levels（with chemiluminescence immunoassay） were determined in 89 patients with gastric carcinoma an well as 66 normal controls and done comparative analysis.Results In blood lipid analysis,serum TC and HDL-C levels were significantly lower in 89 patients with gastric carcinoma than those in 66 controls（P all0.05）,and more lower in paralleled with the severity of gastric cacinoma（P0.05~0.01）.The serum TG and LDL-C levels were a minor increase,but without statistically significance（P0.05）.The 32 patients with Ⅳ stage gastric carcinoma were significantly increase in serum TG and LDL-C levels only（P all 0.05）.The serum CA125,CA15-3 and CA19-9 levels were markedly higher in 89 patients with gastric carcinoma than those in 66 controls（P all 0.05~0.01）,and raising with the severity of gastric carcinoma simultaneously（P0.05~0.01）.Conclusion The patients with gastric carcinoma existed blood lipid metabolic disorder,the serum TC and HDL-C levels were significantly low,but more lower with the degree of severity.The serum CA125,CA15-3 and CA19-9 postive rate were low,these tumer markers might be useful,if combined with other determinations.
出处
《放射免疫学杂志》
CAS
2011年第6期686-688,共3页
Journal of Radioimmanology
关键词
胃癌
血脂
肿瘤标志物
gastric carcinoma
blood lipid
tumor markers
