摘要
为探讨茵陈蒿汤醇提物的保肝作用与机体抗氧化能力的关系，实验观察茵陈蒿汤醇提物在Ｄ─氨基半乳糖＋脂多糖（Ｄ—ＧａｌＮ＋ＬＰＳ）和卡介苗＋脂多糖（ＢＣＧ＋ＬＰＳ）模型中对ＡＬＴ、ＧＳＴ、ＬＰＯ、ＳＯＤ及ＧＳＨ的影响。结果：茵陈蒿汤醇提物ｉｇ．６ｇ／ｋｇ和９ｇ／ｋｇ明显降低Ｄ—ＣａｌＮ＋ＬＰＳ肝损伤小鼠血清谷丙转氨酶（ＡＬＴ）活性，降低谷胱甘肽─Ｓ─转移酶（ＧＳＴ）水平，减少肝匀浆中脂质过氧化物（ＬＰＯ）含量，对超氧化物歧化酶（ＳＯＤ）活性无明显影响；４ｇ／ｋｇ，６ｇ／ｋｓ和９ｇ／ｋｓ显著降低ＢＣＧ＋ＬＰＳ免疫性肝损伤小鼠血清ＡＬＴ水平，６ｇ／ｋｇ和９ｇ／ｋｇ增加肝匀浆还原型谷胱甘肽（ＧＳＨ）含量。表明茵陈蒿汤醇提物经口给药能明显提高小鼠抗自由基损伤的能力，为其保肝作用的机理之一。
The mechanism of protecting mice from experimental liver injury of alcohol extract of Capillaris decoction wereobserved. Elevated serum ALT,GST activity in D-GaiN+LPS liver injury model were reduced by a dose-dependent effect of alcohol extract,coresponding with reduced LPO level. After administration of BCG+LPS, serum ALT level increased significantly.Alcohol extract reduced ALT activity and increased GSH level apparently. These results suggest alcohol extract of Capillaris decoction might protect mice from experimental liver injury,through a way of antilipoperoxidation.
出处
《时珍国医国药》
CAS
CSCD
1999年第11期806-807,共2页
Lishizhen Medicine and Materia Medica Research
关键词
茵陈蒿汤醇提物
免疫性肝损伤
抗氧化作用
Alcohol extract of Capillaris Decoction
BCG+LPS liver injury
D-GaiN+LPS liver injury
