摘要
上海市１９８０～１９９８ 年报告９ 例口服脊髓灰质炎疫苗相关病例（ＶＡＰＰ）。第１ 次服苗者中ＶＡＰＰ的发生率每年是０～３０－３１／１００ 万，平均３－０１／１００ 万；以０～５ 岁服苗人次统计，每年发生率为０ ～５－０３／１００ 万，平均０－５２／１００ 万。发病者全部为男性，年龄１ ～７ 月龄，均为第１ 次服苗。病毒分型以Ⅲ型居多（５ 例），Ⅱ型３ 例，Ⅰ型１ 例。服苗至发病平均潜伏期１５－２２ 天，６０ 天后均残留麻痹，现有临床免疫功能检验未发现免疫功能低下或丙种球蛋白减少。
During 1980～1998, there were 9 cases of vaccine-associated paralytic poliomyelitis (VAPP) found in Shanghai. The epidemiological characteristics of VAPP was summarized as follows: The mean incidence rate of VAPP in the first-dose vaccinated infants the incidence was 3.01/1,000,000, and in the vaccinated children aged 0～5years was 0.52/1,000,000. All the cases of VAPP were male, aged 1-7 months, and they were given first dose OPV. The mean period of incubation was 15.22 days. The types of vaccine-like virus isolated from stools of the cases were: type Ⅰ l case, type Ⅲ 5 cases, type Ⅱ 3 cases. All the cases were treated in hospitals and were tested for immune function, the hypoimmunity and hypogammaglobinemia were not found. To reduce the incidence of the VAPP, we suggest that the first and second doses of polio vaccine are better to use IPV in the cities.
出处
《中国计划免疫》
1999年第6期321-323,共3页
Chinese Journal of Vaccines and Immunization
关键词
口服
脊髓灰质炎
疫苗
免疫缺陷
流行病学
Poliomyelitis vaccine, Vaccine-associated paralytic poliomyelitis (VAPP), Immune deficiency
