摘要
目的探讨血浆脑钠肽(BNP)在COPD中的应用。方法将60例COPD患者分为2组,其中30例伴肺源性心脏病(CP)为Ⅰ组,30例不伴CP为Ⅱ组,测血清BNP水平,同时检测动脉氧分压(PaO2)、动脉血二氧化碳分压(PaCO2),肺通气功能测定一秒用力呼气容积[FEV1(%)],用力肺活量[FVC(%)],彩色多普勒测量肺动脉压(PaP);采用Spearman法行相关性分析。结果 2组患者在年龄,性别构成,吸烟史比较差异均无统计学意义(P>0.05);2组患者测得PaO2、PaCO2,FEV1(%),FVC(%),PAP水平及检测BNP水平,其Ⅰ组均高于Ⅱ组,有统计学意义(P<0.01)。相关性分析表明:BNP检测水平与PaP、PaCO2呈正相关,与动脉血PaO2、FEV1(%)、FVC(%)成负相关。结论检测BNP可为临床诊断COPD伴CP提供有力依据。
Objective We investigated the clinical significance of brain natriuretic peptide（BNP） in chronic obstructive pulmonary disease（COPD）.Methods Subjects were 60 patients with stable COPD,of whom 30 had cor pulmonale（CP）, and 30 without CP.Plasma BNP levels were measured and pulmonary arterial pressure（PAP）was estimated by echocardiography.Arterial blood gas analysis,forced vital capacity（FVC）and forced expiratory volume in 1 s（FEV1）were also recorded.Spearman correlation assay was used to investigate the correlation between BNP and PAO2、PACO2、FEV1（%）、FVC（%）、PAP.Results 60 patients with COPD were diagnosed with CP and without CP no significant differences in age、sex and smoking history.BNP levels of patients with CP had a higher mean BNP level with respect to those without CP.BNP levels correlated with PAP and PACO2 （r=0.66 and =0.64,respectively）,partial arterial oxygen pressure （r=0.46）,FEV1（r=0.48） and FVC（r=0.49）.Conclusion BNP determination has a role in the diagnosis of CP in patients with COPD.
出处
《中外医疗》
2011年第31期9-10,共2页
China & Foreign Medical Treatment
关键词
脑钠肽
慢性阻塞性肺疾病
肺源性心脏病
Brain natruiuretic peptide
chronic obstructive pulmonary disease
cor pulmonale
