摘要
目的利用31P-MRS检测肝细胞癌(HCC),探讨各代谢参数与临床及病理特征的关系。方法对32个肝细胞癌病灶进行单体素31P-MRS扫描。根据手术及病理结果显示有无包膜、肝硬化、侵袭转移性以及恶性程度分别进行分组。根据31P-MRS扫描结果计算肝细胞内pH值(pHi)、磷酸单脂(PME)、磷酸双脂(PDE)、无机磷(Pi)、γ-ATP、β-ATP、α-ATP、PME/ATP、Pi/ATP、PME/PDE、PME/Pi、PDE/Pi、PDE/ATP和低能磷酸盐(LEP)等参数。分析以上代谢参数在各分组之间差异。结果 HCC的pHi、Pi、Pi/ATP、LEP均明显大于周围肝组织,α-ATP和PDE/Pi则相反(P<0.05)。包膜组病灶的β-ATP小于无包膜组(t=2.290,P=0.029)。肝硬化组HCC病灶pHi大于无肝硬化组,而γ-ATP则相反(P<0.05)。侵袭转移组的PME和PME/ATP均明显大于无侵袭转移组(P<0.05)。另外,在HCC高、中、低分化病理类型之间,Pi、Pi/ATP、PME/Pi、PDE/Pi均有统计学差异(P<0.05)。其余代谢参数在以上各种分组之间未见统计学差异(P>0.05)。结论 31P-MRS代谢参数与HCC临床、病理特征具有一定的关系,利用31P-MRS可对HCC的生物学行为进行无创评估。
Objective To examine the relationship between clinical-pathological features and metabolic status of hepatocellular carcinoma（HCC） using in vivo 31P magnetic resonance spectroscopy（31P-MRS）.Methods 31P-MRS scanning with a single voxel was carried out on 32 HCC lesions.Groups were formed for the following： with and without capsula,with and without cirrhosis,and with and without infiltration（intrahepatic daughter foci,tumor-emboli in portal veins and lymphatic metastasis）.Another group was formed according to the pathological grades of the lesions.Intracellular pH value（pHi）,and metabolic parameters including phosphomonoester（PME）,phosphodiester（PDE）,inorganic phosphate（Pi）,γ-ATP,β-ATP,α-ATP,lower energetic phosphate（LEP）,and the ratios PME/ATP,Pi/ATP,PME/PDE,PME/Pi,PDE/Pi and PDE/ATP were calculated.Differences in the metabolic parameters between different groups were analyzed.Results HCC exhibited higher values for pHi,Pi,Pi/ATP and LEP,but lower values for α-ATP and PDE/Pi,than the liver（P0.05）.Lesions with capsula had higher β-ATP than those without（t=2.290,P=0.029）.Lesions with cirrhosis had higher pHi and lower γ-ATP than those without（P0.05）.Lesions with infiltration had higher PME and PME/ATP than those without（P0.05）.Differences in Pi,Pi/ATP,PME/Pi and PDE/Pi of HCC among the three pathological grades were also identified statistically（P0.05）.These groups did not show statistically significant differences for other metabolic parameters（P0.05）. Conclusion Some phosphorus metabolites in HCC are related to clinical-pathological features,and 31P-MRS can be used to evaluate the biological behavior of HCC in a non-invasive fashion.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第11期97-100,共4页
Journal of Shandong University:Health Sciences
关键词
癌
肝细胞
磁共振波谱成像
病理特征
Carcinoma
hepatocellular
Magnetic resonance spectrum
Pathological feature
