摘要
瘢痕是皮肤烧（创）伤、手术后最常见的并发症之一，修复其导致的外观损害和功能障碍是烧伤科医师面临的最棘手问题之一。皮肤损伤及外科手术后瘢痕的总体发病率为40％～70％，烧伤患者的发病率可高达91％。不同国家增生性瘢痕的发病率差异明显，发达国家每年新增瘢痕病例约400万，
Scar, either hypertrophic sear or keloid, is one of the most common complications due to proliferative disorder of fibrosis in the process of wound healing after burn injuries, trauma, and surgical operations. To repair the cosmetic and functional impairments caused by scars poses a great challenge to all the burn surgery workers. With the advances in both basic research and clinical treatment, the understanding of scar formation and the therapeutic strategies of scar have been improved significantly. However, the remaining problems are still outstanding. In this discussion, the advances and problems in tbe scientific research in this field, including genetic predisposi- lion, candidate gene, dysfunction of fibroblasts, interaction between fibroblasts and keratinoeytes, as well as animal models for hypertrophic scar and keloid were summarized. In addition, the progresses in the clinical therapies are also discussed, including pressure treatment, silicone gel sheeting, corticosteroids, laser, and other emerging treatment strategies. The understanding and treatment of sear will improve in the future with further deepe- ning basic research and clinical trials with stricter standard of assessment.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2011年第6期407-410,共4页
Chinese Journal of Burns
关键词
烧伤
瘢痕
创面愈合
Burns
Cicatrix
Wound healing
