摘要
目的观察扶正解毒活血胶囊序贯治疗慢性乙型肝炎(CHB)的临床疗效。方法将91例CHB患者随机分为两组,对照组(45例)口服拉米夫定片、联苯双酯滴丸、肌苷,治疗组(46例)在此治疗基础上,依次口服扶正解毒活血胶囊Ⅰ号、Ⅱ号、Ⅲ号各90天。两组疗程均为270天,第0(治疗前)、30、60、90、180、270天检测肝功能、乙肝病毒(HBV)五项、HBV-DNA载量和肝纤维化指标,进行临床症状评分。结果两组治疗后不同时间点丙氨酸氨基转移酶(ALT)复常率均明显提高(P<0.05),但两组间同时间点比较差异无统计学意义(P>0.05);HBV-DNA和乙型肝炎病毒e抗原(HBeAg)转阴率、乙型肝炎病毒表面抗原/乙型肝炎病毒表面抗体(HBsAg/HBsAb)及乙型肝炎病毒e抗原/乙型肝炎病毒E抗体(HBeAg/HBe-Ab)转换率治疗组均高于对照组,但差异无统计学意义(P>0.05);治疗后两组肝纤维化指标均明显下降,但治疗组比对照组下降幅度更大(P<0.05);治疗后临床症状总积分减少两组差异有统计学意义(P<0.05)。结论扶正解毒活血胶囊序贯治疗CHB有较好的综合疗效,可在一定程度上克服HBV耐药与变异。
Objective To observe the effect of sequential of Fuzheng Jiedu Huoxue Capsule （Capsule for reinforcing resistance, removing toxins, and activating blood circulation） treatment on chronic hepatitis B （CHB）. Methods Totally 91 CHB patients were randomized into two groups. The control group of 45 cases were administered lamivudine tablets, bifendate pills, and inosine tablets. Additionally, the treatment group was given sequentially Ⅰ, Ⅱ, and Ⅲ, each for 90 days. The course of treatment was 270 days in total. Before treatment and on the 30th, 60th, 90th, 180th, and 270th day of treatment, the liver function, hepatitis B virus （HBV） five items, HBV-DNA capacity, and indices of liver fibrosis were detected and the main symptom scores were recorded. Results The negative conversion rate of alanine aminotransferase （ALT） in both groups was improved （P0.05）, but the difference between groups at the same time point was not significant （P0.05）. The HBV-DNA and the negative conversion rate of HBeAg, the HBsAg/HBsAb, and the transformation rate of HBeAg/HBeAb of the treatment group were all higher than those of the control group, but the difference was not significant （P0.05）. After treatment, the indices of liver fibrosis of both groups were significantly decreased, but the amplitude of decrease in the treatment group was larger （P0.05）. The total score of main symptoms in the treatment group was reduced, and the difference between the two groups was statistically significant （P0.05）. Conclusion The sequential treatment of Fuzheng Jiedu Huoxue Capsule is comprehensively effective on CHB, to a certain degree, it overcomes the resistance and variation of HBV.
出处
《中医杂志》
CSCD
北大核心
2011年第23期2017-2020,共4页
Journal of Traditional Chinese Medicine
基金
湖南省教育厅资助项目(06C748)
邵阳市科技局资助项目(N0958)
关键词
慢性乙型肝炎
扶正解毒胶囊
拉米夫定
序贯治疗
chronic hepatitis B （CHB）
Fuzheng Jiedu Huoxue Capsule （Capsule for reinforcing resistance
removing toxins
and activating blood circulation）
lamivudine
sequential treatment
