摘要
目的观察阿托伐他汀钙对于高血压患者颈动脉内-中膜厚度(CIMT)的影响。方法观察2005年9月～2010年9月本院门诊及住院伴CIMT增加的高血压患者99例,随机分为阿托伐他汀钙组(51例)及对照组(48例)。阿托伐他汀钙组(A组)在限盐、合理饮食、加强体育运动、规范达标降压治疗基础上给予阿托伐他汀钙20mg每晚一次,疗程24.3月至51.5月不等,平均38.4月。对照组(B组)采用与干预组同样措施,但未用他汀类药物。治疗后两组每3～6个月复查一次颈动脉多普勒超声。结果与B组比较,A组接受阿托伐他汀钙24.3月后CIMT开始有较明显的延缓,38.4月时更为明显(P<0.05)。结论他汀类药物可延缓、逆转高血压患者颈动脉内膜的增厚。
Objective To observe the effect of atorvastatin on carotid intima-media thickness （CIMT） in patients with hypertension. Methods During periode of Sept 2005 to Sept 2009, 99 patients （including in- and outpatients）＂ with hypertension complicated abnormal CIMT were randomly divided into two groups. Group A （51 cases） with 20 mg of atorvastatin each day, per os. Group B （48 cases） as control group. Two groups of patients were all on the basis of salt restrict, rational diet, adhere to exercise and reach the standard goal of antihypertensive treatment. Coarse of observation was 24.3 m to 51.5 m, mean 38.4 months. Every 3-6 months patients were reexamined by Doppler echo. Results Comparing with group B, CIMT inceasing were evidently delayed in Patients of group A, This changes occurred during 24.3 m, especially comfirmed during 38.4 months（P〈0.05）. Conclusion Drug of statins provided a effect to delaye the increasing of abnormal carotid intima-media thickness （CIMT） in patients with hypertension.
出处
《心血管病防治知识（学术版）》
2011年第6期18-21,共4页
Prevention and Treatment of Cardiovascular Disease
