摘要
多种肾上腺疾病存在骨骼肌胰岛素抵抗（IR）现象。醛固酮通过影响胰岛素受体功能和信号转导，或通过诱导氧化应激导致骨骼肌IR；糖皮质激素干扰胰岛素信号和糖原合成，或促进脂肪分解，减少骨骼肌胰岛素介导的葡萄糖摄取；儿茶酚胺诱导或加重骨骼肌IR，可能与血清脂联素水平下降有关；肾上腺偶发瘤患者骨骼肌IR发生率增加，这可能与亚临床前炎性反应因子作用有关。
The phenomenon of skeletal muscle insulin resistance （IR） appears in several adrenal diseases. Aldosterone is associated with IR in skeletal muscle either through its effects on the insulin receptor function and signaling trasduction, or through oxidative stress induction. Glucocorticoids reduce insulin-media- ted glucose uptake in skeletal muscle, either by perturbing insulin-signaling and glycogen synthesis, or by pro- moting lipid metabolism. Catecholamine can induce or aggravate IR in skeletal muscle which may be related to hypoadiponeetinemia. Patients with adrenal incidentalomas have increased prevalence of skeletal muscle IR,which may possibly due to the subclinical proinflammatory milieu.
出处
《国际内分泌代谢杂志》
2011年第6期412-414,417,共4页
International Journal of Endocrinology and Metabolism
基金
天津市自然科学基金资助项目（10JCYBJC13200）
关键词
肾上腺疾病
胰岛素抵抗
骨骼肌
Adrenal diseases
Insulin resistance
Skeletal muscle
