摘要
目的观察肠易激综合征(IBS)的有效治疗途径及匹维溴铵(得舒特)治疗的疗效。方法本研究为随机对照临床试验。将38例IBS病人随机分为3组,得舒特组18例,谷维素组10例,对照组10例。4周后比较疗效、心理卫生状况评价(HAMA、HAMD)。结果治疗前3组症状比较差异无统计学意义(P>0.05);治疗后在缓解腹痛、腹泻、腹胀、便秘症状上,得舒特组明显优于谷维素组和对照组(P<0.05)。治疗前HAMA、HAMD评分达到轻-中度焦虑、抑郁水平;治疗后HAMA、HAMD评分都有明显下降(P<0.01)。结论得舒特能有效改善IBS患者的肠道症状和心理状况,若联用心理治疗可增强得舒特的疗效。
Objective To investigate the effect of pinaverium bromide on irritable bowel syndrome （IBS）.Methods 38 patients with IBS were randomly divided into 3 groups： pinaverium bromide group （18 cases） treated with pinaverium bromide,oryzanol group （10 cases） treated with oryzanol,and control group（10 cases） treated with starch After 4 weeks,the effects of the drugs were evaluated by the changes of IBS-associated symptoms and psychological status （HAMA,HAMD）.Results Before treatment,there were no differences among the status （P〈0.05）,IBS patients in three groups were in the mild status of anxiety and depression.After 4 weeks,the pinaverium bromide group relieved markedly （P〈0.05） among the three groups in the improvement of the predominant symptoms （such as abdominal pain,diarrhea,distension and constipation）;the decreases of HAMA and HAMD scores in three groups were significant （P〈0.01）.Conclusion Pinaverium bromide can significantly improve the symptoms of IBS and psychological symptoms,that were reinforced the effects by the aid of psychological therapy.
出处
《临床合理用药杂志》
2011年第10X期43-45,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
肠易激综合征
匹维溴铵
治疗结果
Irritable bowel syndrome
Pinaverium bromide
Treatment outcome
