摘要
目的:通过检测急性缺血性脑卒中(IMS)患者血清超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)含量的变化,探讨上述炎性介质及炎性细胞因子对IMS的检测价值。方法:选择发病24h内住院的IMS患者68例,并按神经功能缺损评分方法分为轻度缺损组(A组,n=30)、中度缺损组(B组,n=22)和重度缺损组(C组,n=16)。选取30例体检无急性缺血性脑卒中者作对照组,检测血清TNF-α、IL-6和hs-CRP水平。结果:IMS患者血清hs-CRP、TNF-α和IL-6水平均明显高于正常对照组(P<0.05);A组、B组和C组较正常对照组均有不同程度的增高,且随患者神经损害程度的加重而显著升高(P<0.05或P<0.01)。结论:血清hs-CRP和炎性因子TNF-α和IL-6水平可作为IMS患者病情评估的有效指标。
Objective：To assess the prognostic values of hs-CRP,TNF-α and IL-6 in ischemic stroke,and compare the level of serum hs-CRP,TNF-α and IL-6 in acute cerebral infarction（IMS） group with that of the normal control group.Method：68 IMS patients were included in this study,which were in hospital within 24 hours after ischemic stroke.These patients were set into three groups under the index of ischemic stroke,including mild impairment（group A,n=30）,moderate impairment（group B,n=22） and severe impairment（group C,n=16）.There were 30 normal persons as a control group.The level of serum hs-CRP,TNF-α and IL-6 were detected.Results：The serum hs-CRP,TNF-α and IL-6 levels in IMS patients were significantly higher than the normal control group（P0.05）.The serum levels of hs-CRP,TNF-α and IL-6 in group of group A,group B and group C were significantly higher than the normal control group gradually（P0.05 or P0.01）.Conclusion：hs-CRP,TNF-α and IL-6 were markers of acute ischemic stroke.
出处
《微循环学杂志》
2011年第4期51-52,55,I0003,共4页
Chinese Journal of Microcirculation
