摘要
目的观察补肾壮骨颗粒对骨质疏松症雌性大鼠的体重和骨组织计量学的影响,探讨去势后雌性大鼠体重变化与骨质疏松症的关系。方法 58只雌性大鼠被分为5组:假手术组、模型组、阳性药组、补肾壮骨颗粒高剂量组和补肾壮骨颗粒低剂量组,采用去势方法造成雌性大鼠骨质疏松模型,连续给药13周,观察各组大鼠体重及骨组织计量学指标的变化。结果与模型组对照,补肾壮骨颗粒高剂量组去势雌性大鼠的体重增长速度显著减缓(P<0.05),其骨组织计量学指标显著改善(P<0.05);阳性药组的体重增长速度在13周后显著减缓(P<0.05),但骨组织计量学指标无明显改善(P>0.05);补肾壮骨颗粒低剂量组的体重增长速度及骨组织计量学指标差异均无统计学意义(P>0.05)。结论补肾壮骨颗粒可改善去势造成的骨质疏松雌性大鼠模型的骨组织计量学指标,同时减缓其体重增长速度。
Objective To evaluate the effects of Bushen Zhuanggu Granules on body weight and bone histomoro phometry of female rats with emasculation - induced osteoporosis, and to analyze the correlation between the ponderal growth and osteoporosis in emasculated female rats. Methods Fifty - eight female rats were randomly divided into 5 groups ： sham - operation group, model group, positive - drug control group, high - dosage group and low - dosage group. Osteoporosis rat model was established by emasculation. The duration of administration was 13 weeks. Ponderal growth and indices of bone histomorphometry was recorded for analysis. Results Compared with model group, ponderal growth was significantly retarded in high - dosage group, with significant improvement of bone histomorphometry indite （P 〈 0.05）. Conclusion Bushen Zhuanggu Granules can improve the indices of bone histomorphometry of female rats with emasculation - induced osteoporosis and slow down the ponderal growth.
出处
《广东医学》
CAS
CSCD
北大核心
2011年第18期2357-2359,共3页
Guangdong Medical Journal
基金
广东省自然科学基金资助项目(编号:9152500002000003)
