摘要
目的:探讨狼疮肾炎(Lupus nephritis,LN)血浆中Th17细胞相关的细胞因子(Interleukin,IL)-17、IL-6、IL-23、IL-27和转化生长因子β(Transforming growthfactor-beta,TGF-β)水平的变化。方法:实验组分为系统性红斑狼疮(Systemic lupus erythe-matosus,SLE)有活动性肾脏病变组的患者23例,无肾脏病变组的SLE患者20例;健康对照组20例。采用酶联免疫吸附法测定血浆中IL-17、IL-6、IL-23、IL-27和TGF-β水平,分析它们的相关性。结果:SLE患者与健康对照组比较血浆中IL-17、IL-6、IL-23和IL-27的浓度都明显升高,TGF-β的血浆浓度则明显降低,而且实验组与健康对照组之间的差异具有统计学意义(P<0.05)。SLE有活动性肾脏病变和SLE无肾脏病变组之间比较,有活动性肾脏病变组IL-6升高更明显,TGF-β的血浆浓度降低更明显,且有统计学差异(P<0.05)。而IL-17、IL-23和IL-27在实验组之间则无明显的差异。IL-17与IL-6、IL-23和IL-27之间呈正相关,与TGF-β之间则呈负相关。结论:IL-17及其相关的细胞因子在SLE表达异常,但IL-17的表达与SLE肾脏病变无相关性。
Objective：To analyze the levels of T helper（Th）17-related cytokines interleukin（IL）-17,IL-6,IL-23,IL-27 and transforming growth factor-beta（TGF-β） in plasma of lupus nephritis（LN）.Methods：The patients groups included 23 patients of systemic lupus erythematosus（SLE） with active renal disease and 20 patients of SLE without renal disease;the control group include 20 healthy.Plasma levels of IL-17,IL-6,IL-23,IL-27 and TGFβ were measured by enzyme-linked immunosorbent assay.And analyzed their correlations.Results：The levels of IL-17,IL-6,IL-23 and IL-27 were higher in SLE patients compared with healthy controls.The levels of TGF-β were significantly decreased in SLE patients than in healthy controls,and their difference was significant（P0.05）.When compared SLE patients with active renal disease and without renal disease,IL-6 level was higher and TGF-β level was decreased in the former,these difference was significant（P0.05）.In contrast,the levels of IL-17,IL-23 and IL-27 were no difference in two groups of SLE patients.IL-17 level was correlated positively with the levels of IL-6,IL-23 and IL-27.IL-17 was correlated negatively with TGF-β.Conclusion：The expression of IL-17 and it′s related cytokines were abnormal in SLE,but there was no correlation with the expression IL-17 and SLE patients with or without renal disease.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2011年第9期828-831,共4页
Chinese Journal of Immunology
基金
河北省卫生厅重点课题研究计划(20090071)
