摘要
目的观察加巴喷丁(GBP)灌胃对小鼠镇痛、自主活动和学习记忆的影响。方法按分层随机区组设计,将200小鼠分为甩尾法、扭体法、镇静实验、避暗法和跳台法实验组,每实验组40只小鼠,再分为4小组(n=10):生理盐水组(NS组),3个剂量(50,100,200 mg·kg-1)GBP组即GBP50、GBP100、GBP200组。给药一次后,测试小鼠甩尾潜伏期、15 min内扭体次数、5 min内自主活动次数、避暗潜伏期及错误次数、跳台潜伏期及错误次数。结果在甩尾法和扭体法实验中,GBP可产生镇痛作用(P<0.05或P<0.01);自主活动实验中,G100、G200组小鼠表现有镇静作用(P<0.01);在避暗实验和跳台实验中,G100、G200组的潜伏期缩短,错误次数增加(P<0.05)。结论加巴喷丁灌胃产生了镇痛、镇静和遗忘作用。
Objective To observe the effects of gabapentin（GBP） administered intragastrically on analgesia,locomotor activity and learning and memory function in mice.Methods Two hundreds mice were divided randomly into 5 test groups： tail-flick test group,writhing test group,sedation test group,step-through test group and step-down test group,40 mice per test group,each test group divided into 4 groups（n=10） again： saline group（NS group）,GBP 50,100,200 mg·kg-1（GBP50,GBP100,GBP200 groups） groups.Tail-flick latency,writhing times in 15 min,locomotor activity in 5 min,the latency and error times in learning and memory test were conducted.Results Compared with NS group,gabapentin had analgesic effects（P 0.05 or P 0.01）;G100,G200 groups showed sedative effects（P 0.01）;the latency decreased and error times increased（P 0.05）.Conclusion GBA may be produce the effects of analgesic,sedation and amnesic.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2011年第11期877-879,885,共4页
The Chinese Journal of Clinical Pharmacology
基金
高等学校大学生实践创新训练计划基金资助项目(2010798)
关键词
加巴喷丁
镇痛
镇静
学习记忆
痛阈
gabapentin
analgesic
sedation
learning and memory
threshold of pain
