摘要
不耐热肠毒素B亚单位(heat—labile enterotoxin Bsubunit,LTB)是产肠毒素性大肠杆菌分泌到细胞周质的肠毒素的组成部分,具有黏膜免疫佐剂活性,可介导细菌与肠上皮细胞结合。此文对LTB的结构、重组表达、作为黏膜佐剂的免疫学评价和作用机制等方面进行综述。
Heat-labile enterotoxin B subunit (LTB) is a part of enterotoxin secreted into cellular periplasm by enterotoxigenic Escherichia coli (ETEC). LTB has mucosal immunoadjuvant activity, and can mediate ETEC binding to intestinal epithelium cells. This paper summarizes structure, recombination expression, immunity evaluation as mucosal adjuvant and effect mechanism of LTB.
出处
《国际生物制品学杂志》
CAS
2011年第5期262-266,共5页
International Journal of Biologicals
关键词
肠毒素类
免疫
黏膜
佐剂
免疫
Enterotoxins
Immunity, mucosal
Adjuvants, immunologic