摘要
观察TP方案化疗序贯三维适形放疗在食管癌治疗中疗效及不良反应。76例符合标准的食管癌患者,随机分为治疗组和对照组。治疗组先予TP方案化疗4个周期,后行三维适形放射治疗;对照组单用三维适形放射治疗。结果76例患者均可进行评价。治疗组有效率(RR)为92.1%(35/38),对照组RR为81.6%(31/38),两组间比较差异无统计学意义,χ2=1.842,P=0.175。治疗组中位生存时间为28个月,对照组为24个月。1、2、3年生存率:治疗组为81.6%(31/38)、60.5%(23/38)和36.8%(14/38);对照组为71.1%(27/38)、50.0%(19/38)和28.9%(11/38);两组生存曲线比较差异无统计学意义,χ2=0.927,P=0.336。两组不良反应主要有白细胞减少、放射性食管炎、放射性肺炎和恶心呕吐等;治疗组3～4级白细胞减少发生率为84.2%(32/38),对照组为10.5%(4/38),两组间比较差异有统计学意义,χ2=41.378,P=0.000;余不良反应两组间比较差异无统计学意义。初步研究结果提示,TP方案化疗序贯三维适形放疗治疗食管癌安全有效,值得进一步扩大样本研究。
The objective of this study was to observe the effectiveness and adverse reaction about sequential chemotherapy with taxol plus cisplatin（TP） and three dimensional con formal radiation therapy（3D-CRT） in esophageal cancer. Totally 76 patients with esophageal cancer enrolled in this study were equally randomized into two groups： the research group with 38 patients who were given sequentially 4 cycles of chemotherapy （TP） and radiotherapy （3D-CRT）, the control group with 38 patients who were given radiotherapy （3D-CRT） only. All 76 cases were evalu able for objective response. Though the complete and partial remission rate （CR＋PR） was 92. 1%（35/38） in the re search group and 81. 6%（31/38） in the control group, and there was no significant difference （2.2 1. 842,P= 0. 175）. The median survival was 28 months in the research group and 24 months in the control group. The 1 , 2 and 3 year overall survival rate was 81. 6% （31/38）, 60. 5% （23/38）, 36.8% （14/38） in the research group, 71. 1 （27/38）,50.0%（19/38）,28.9%（11/38） in the control group,and there was no significant difference （x2= 0. 927, P= 0. 336）. Many adverse reactions were observed in the research group and the control group such as WBC decrease, esophagitis, pneumonitis,etc,excluding 3 to 4 WBC decrease＇s incidence rate was 84.2 % （32/38） in the research group and 10.5 % （4/38） in the control group （x2=41. 378, P = 0. 000）. In conclusion, Sequential chemotherapy with TP and 3D-CRT is effective and safe in esophageal cancer.
出处
《中华肿瘤防治杂志》
CAS
2011年第20期1646-1648,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
食管肿瘤/药物疗法
食管肿瘤/放射疗法
综合疗法
放射疗法
适形
esophageal neoplasms/drug therapy
esophageal neoplasms/radiotherapy
combined modality therapy
radiotherapy, conformal
