摘要
目的了解鲍曼不动杆菌的临床分布特点及其耐药性,为临床合理用药提供依据。方法对2008年1月-2010年12月湖南省儿童医院临床分离的348株新生儿鲍曼不动杆菌的分布及耐药情况进行回顾性分析。结果 348株鲍曼不动杆菌主要分离自患者痰和气管分泌物标本（93.10%,4.02%）,其次为血液、创面分泌物、脑脊液、脓液标本,分别占1.44%、0.57%、0.57%、0.28%。鲍曼不动杆菌对替卡西林、头孢噻肟、头孢替坦、呋喃妥因、头孢唑啉、氨苄西林、阿莫西林/克拉维酸、阿莫西林表现为较高的耐药率,为91.09%~99.71%;鲍曼不动杆菌医院感染株32株,占9.20%。鲍曼不动杆菌医院感染组（HA-Ab）对多种抗菌药物耐药性明显高于鲍曼不动杆菌社区感染组（CA-Ab）。结论鲍曼不动杆菌主要分离自呼吸道标本,对头孢唑啉、头孢噻肟等临床常用抗生素耐药,而对美罗培南和阿米卡星、哌拉西林/他唑巴坦有较高的敏感性,儿科应加强对鲍曼不动杆菌的监测,合理选择抗菌药物,制定有效的感染控制措施,预防和控制医院感染的发生。
Objective To investigate the clinical distribution and antimicrobial resistance of Acinetobacter baumanni（Ab）,and to provide the evidence for rational use of drugs in clinical practice. Methods We retrospectively analyzed the clinical distribution and antimicrobial resistance of 348 Ab strains which were isolated from newborns hospitalized in the Children＇s Hospital of Hunan Province from January 2008 to December 2010. Results Most of 348 Ab strains were isolated from sputum（93.10%） and tracheal secretions tract（4.02%）,followed by blood（1.44%）,secretions of surgical wounds（0.57%）,cerebrospinal fluid（0.57%） and pus（0.28%）.The resistance rates of Ab to ticarcillin,cefotaxime,cefotetan,furantoin,cephazolin,ampicillin,amoxicillin/clavulanic acid,and amoxicillin were high,with the rates of 91.09%～99.71%.There were 32 strains of hospital-acquired Acinetobacter baumanni（HAAb）,accounted for 9.20%.The results of comparison of the antibiotic resistance rates of community-acquired Acinetobacter baumanni（CA-Ab） and HA-Ab to various antibacterial drugs showed that the drug resistance rates of the former were significantly lower than those of the latter. Conclusions Most of 348 Ab strains were isolated from respiratory tract.Ab has a strong resistance to cefazolin and cefotaxime which commonly used in clinical treatment,but it is relatively sensitive to meropenem,amikacin and piperacillin/tazobactam.It is necessary to strengthen Acinetobacter baumanni resistance monitoring in department of pediatrics,use antibiotics rationally,formulate effective infection control measures,and prevent and control the occurrence of nosocomial infections.
出处
《实用预防医学》
CAS
2011年第11期2187-2189,共3页
Practical Preventive Medicine
关键词
鲍曼不动杆菌
新生儿
药物敏感性
Acinetobacter baumanni
Neonates
Drug susceptibility
