摘要
将小鼠置通有96%N_2、4%O_2混合气的缺氧罐中,动物在72秒钟左右死亡。缺氧前30分钟腹腔注射慢心律6.25～50mg kg 或苯妥英钠12.5～100mg kg 能明显延长缺氧小鼠的存活时间,在一定范围内存在着剂量与效应关系。采用小鼠断头法引起脑缺血30秒后脑组织乳酸含量明显升高。慢心律及苯妥英钠可明显降低小鼠脑缺血后的乳酸升高。这说明慢心律和苯妥英钠对小鼠脑缺血及缺氧有一定的保护作用。
Albino mice Only could survived 72±14 sec((?)±S)when they inspired 4% oxygeninstead of air.Mexiletine(6.25 to 50mg/kgor Phenytoin sodium(12.5 to 100 mg/kg)prolonged the survival time markedly when thedrugs were administered intraperitoneally(i.P.30min prior to hypoxia.The highest dosesof mexiletine was 50mg/kg,and phenytoinwas 100mg/kg,Our dose may cause somebehavior abnormality.In addition,both drugsprotected ischemic brain from accumulatinglactic acid if the drug was injected i.P.30min before decapitation and the animal's headswere kept at room temperature(25 to 29℃)for 30 sec.These findings suggest thatmexiletine and Phenytoin are effective againsthypoxia and brain ischemia in mice.
出处
《中华神经外科杂志》
CSCD
北大核心
1990年第S1期28-30,90,共4页
Chinese Journal of Neurosurgery
