摘要
本文通过实验研究和10年临床、现场动态观察,探讨了工业性氟病的早期表现和防治措施。结果表明,尿氟、尿羟、骨氟、骨骼X线征象及病理改变与氟暴露呈剂量-反应关系;氟对骨外系统影响的早期表现为肾超微结构、肾酶和尿酶活性、免疫功能改变。通过动态观察,实施的车间改造、工艺改革、个人防护等,以及硼的预防性治疗等综合性防治措施已取得明显效果。
The early manifestations and comprehensive preventive measures for industrial fluorosis were explored by means of the systematic experimental researches and ten years' observations in clinic and at workplaces.Our experimental results showd that the doses of fluoride exposure were related to the contents of urinary fluoride,urinary hydroxyproline and bony fluoride,to the changes of bony X-ray and pathology,and that the early manifestations of fluorosis in extrabony systems were the changes in renal ultrastructures,renal and urinary enzyme activities,and immune functions.According to the ten years' observations,the comprehensive preventive measures,including workshop and technique improvements,individual protection and antidote administration,were performed with remarkable results.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
1990年第S1期52-54,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
关键词
氟化物中毒
早期表现
预防医学
fluoride poisoning
early manifestations, preventive medicine
