摘要
对发病8h以下急性心肌梗塞(AMI)患者28例及健康人20例进行了血浆氨基酸含量测定,并对前者进行了分组对照治疗,结果表明:AMI患者血浆谷氨酸含量明显降低(P<0.01),丙、甘、缬,苯丙氨酸含量明显升高,丙氨酸升高最为显著(P<0.001),并且谷氨酸含量与血清cPK—MB含量呈负相关,而丙、甘、结、笨丙氨颈含量与EPK—MB含量呈正相关。根据谷氨酸含量下降及/或丙氨酸含量升高的程度,可推断病情的严重度和预后。分组治疗表明谷氨酸治疗组无论在缩小梗塞范围抑或改善心脏功能及使谷氨照丙氨酸回复到正常水平方面均优于对照组,提示AMI再灌注期间补充一定量的谷氨酸是有益的。
Plasma aminoacid levels were measured in 28 patients with AMI within 8 hours after attack and 20 healthy controls. The results showed that glutamine level was significantly low(P<0.01)and alanine, glyline, valine, phenylalanine level were significantly high, alanine level was highest(P<0.001). Glutamine level was positively correlated with serum CPK-MB level and alanine. glycine, valine, and phenylalaninc level were negatively correlated with serun CPK-MB level. Severity and the prognosis may be infered according to decreased degree of glutamine and/or increased degree of alanine. It was showed that the group treated with glutamine were with better effect than the control group in decreasing infarction area, improving cardiac function and rising glutamine and alanine to normal level.
出处
《中国医科大学学报》
CAS
CSCD
1993年第S1期77-80,83,共5页
Journal of China Medical University
关键词
心肌梗塞
血浆
氨基酸
myocardial infarction
plasma
aminoacid
