摘要
将127例慢性肾衰(CRF)非透析患者根据病因与治疗方法分四组进行前瞻性临床治疗研究,以探讨不同病因CRF的特点及其对大黄治疗的反应。经过平均22.4±10.2(6～57)个月的随访研究发现:①不同病因的CRF各具特点,肾炎引起的CRF较肾功能水平相当的小管间质疾病者病情发展快,远期存活率低,高血压发生率高,蛋白尿及高胆固醇血症明显,并以男性患者居多;②大黄能够延缓CRF的进展,减轻蛋白尿,改善低蛋白血症,纠正脂质代谢异常,提高患者的生活质量;③大黄对肾炎所致CRF的治疗作用较小管间质疾病所致者更为显著。
In order to reveal the characteristics and features of CRF with various underlying diseases and the response to Rheum officinale(RO)therapy, 127 patients with mild to moderate CRF were involved in a prospective clinical trial. They were divided into 4 groups: GN group, GN treated with RO, TIN group, TIN treated with RO, and were followed up for 22.4±10.2(6～57) months. It was shown that there were more rapid progress of CRF, lower longterm survival rate, higher incidence of hypertension, heavier proteinuria, severer hypercholesterolemia in patients with GN than those with TIN. RO could slow the progression of CRF and decrease the protein excretion in urine. Lipid abnormalities, protein metabolism and the quality of life were improved after receiving RO. The beneficial effect of RO on CRF was much more prominant in patients with CN than those with TIN.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1993年第1期66-70,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
慢性肾衰
大黄
肾炎
肾小管间质疾病
chronic renal failure
Rheum Officinale
glomerulonephritis(GN)
tubulointerstitial nephritis (TIN)
