摘要
A series of dialkylaminoalkyl thioesters of α-keto thiohydroximic acid （4-RC<sub>6</sub>H<sub>4</sub>-COC·（NOH）-S-（CH<sub>2</sub>）<sub>n</sub>-NR′R″） as acetylcholinesterase （ACHE） reactivators in vitro were reported, whose correlations between oxime acid（α-keto thiohydromate acid） dissociation constants （pKa）, Hammett values（σp） and rate of AChE reactivation were discussed by Bedford etal. They were considered as nonquaternary AChE reactivators based on the classical reactivative theory by the authors.
基金
Project supported by the National Natural Science Foundation of China.
