摘要
High energy proton is an important type of the space radiation. The paper investigates the radiatione ffect of high energy proton (27.9 MeV) on DNA aqueous solution in the field of the molecular mechanism. The following information about the microcosmic damage to the space structure of DNA was obtained: (ⅰ) breakage of a part of interbase hydrogen bonds which maintained double helical structure of DNA; (ⅱ) damage on four bases, in which the damage on adenine ring was the most serious; (ⅲ) obvious change of deoxyribose; (ⅳ) serious damage on backbone phosphate ion (PO_2^-) and phosphate diester (PO_2) and the occurrence of scissions of double-stranded and single-stranded DNAs; (ⅴ) obvious decrease in the amount of B-form conformation.
High energy proton is an important type of the space radiation. The paper investigates the radiatione ffect of high energy proton （27.9 MeV） on DNA aqueous solution in the field of the molecular mechanism. The following information about the microcosmic damage to the space structure of DNA was obtained: （ⅰ） breakage of a part of interbase hydrogen bonds which maintained double helical structure of DNA; （ⅱ） damage on four bases, in which the damage on adenine ring was the most serious; （ⅲ） obvious change of deoxyribose; （ⅳ） serious damage on backbone phosphate ion （PO<sub>2</sub><sup>-</sup>） and phosphate diester （PO<sub>2</sub>） and the occurrence of scissions of double-stranded and single-stranded DNAs; （ⅴ） obvious decrease in the amount of B-form conformation.
基金
Project supported by the National Natursl Science Foundation of China.
