摘要
用在体大鼠心肌缺血再灌性心律失常模型观察血小板与再灌性心律失常的关系及槲皮素对其的影响。再灌注前２ｍｉｎｉｖ槲皮素（５ｍｇ·ｋｇ－１）可显著降低室颤发生率和血浆ＴＸＢ２值，明显改善血小板超微结构，增加Ｋｅｔｏ—ＰＧＦ１ａ值和血小扳数。结果显示，相应素抗大鼠再灌性心律失常作用与抑制血小板聚集，ＴＸＡ２形成及增加ＰＧＩ２的产生，改善血小板超微结构有关。
heroleofplateletsinreperfusionarrhythmias(RA))andtheefficacyofquercetin(Qne)inpreventingarrhythmiaswereinvestigatedinanesthetisedrats.ThePretreatmentwithQue(5mg.kg-1)2minPriortoreperfusioninhibitedRA.oneremarkablyapprovedtheultrastructuraldeviationofplatelet,inhibitedtheplateletaggregationandthromboxaneA2(TXA2)formationincreasedtheprostacyclin(PGI2)generationandtheratioofPGI2/TXA2.TheresultsshowedthatQneproducedaprotectiveeffectagainstRAProbablythoughinhibitingthePlateletaggregation,TXA2formationandincreasingthePGI2generation.
出处
《苏州大学学报（医学版）》
CAS
1994年第6期483-486,共4页
Suzhou University Journal of Medical Science
