摘要
１９７９年１月至１９９０年１２月共收治原发于鼻腔非何杰金淋巴瘤１１２例，Ⅰ期７９例，Ⅱ期２５例，Ⅲ期３例，Ⅳ期５例。所有病例经病理证实为弥漫性非何杰金淋巴瘤。单纯放疗５１例，放疗和化疗综合治疗５８例，单纯化疗３例。４７例治疗失败，占４２％。其中４２例复发，５例在疗中病变进展。远处节外器官受侵是治疗失败的主要原因，其中以皮肤皮下最多见，淋巴结受侵和局部失败少见。治疗失败和临床分期相关，Ⅰ期极少局部和远处复发，中晚期则明显增多。复发与病理类型无明显关系。在病变超出鼻腔侵犯邻近器官的Ⅰ期病人中，综合治疗组和单纯放疗组远处失败基本相似，和化疗关系不大。Ⅱ期综合治疗病人远处器官受侵明显低于单纯放疗病人。因此，我们认为，选用强烈有效的化疗方案能降低中晚期患者远处器官失败，以提高生存率。复发多在２年内发生，复发病人的再治效果差，预后差。
AbstractOne hundred and twelve patients with non-Hodgkins, lymphoma of diffuse type including 79Stage Ⅰ,25 Stage Ⅱ, 3 Stage Ⅲ and 5 Stage IV patients. Fifty-one were treated with radiotherapyalone, 3 with chemotherapy alone, 58 with combination of radiotherapy and chemotherapy。 Re-lapse developed in 47 patients。 Relapse usually occured within 2 vears。The distant extranodalspread especially in skin was the primary cause of failure。 The local and nodal recurrences wereunusual。 No close relationship was found between histologic classification and recurrence. StagesⅡ,Ⅲ and Ⅳ had higher relapse and poorer prognosis as compared with those of stage I. It issuggested that multimodality for late stage patients may reduce spread of this disease.
出处
《中华放射肿瘤学杂志》
CSCD
1994年第4期224-227,289,共5页
Chinese Journal of Radiation Oncology
