摘要
作者对广州地区汉族人中120例十二指肠溃疡（DU）病人和98例健康人的HLA-A，B抗原进行了检测。结果显示：120例DU病人HLA－B46阳性者51例（42．50％），明显高于对照组（21．43％）（P＜0．05）；其中59例单发DU病人阳性31例（52．54％），18例小弯侧DU病人阳性11例（61．11％），其频率亦均显著高于对照组（分别为P＜0．01和0．05）。30例大弯侧DU病人无一例HLA-A9阳性，明显低于对照组（32．65％）（P＜0．01）。提示HLA-B46与广州地区汉族人的DU有一定的关联。此结果类似其他结果不一的报道，说明与文献有共识，HLA与DU的关联随地区、种族和病人群体的不同而有异。因此，目前HLA仍未能作为一个好的生理参数以理解消化性溃疡的遗传异质性。
HLA-A,B typing of 120 patients with duodenal ulcer (DU) and 98 normal subjects of Han Nationality in Guangzhou were tested. The positive rate of HLA-B46 was 42. 50% (51/ 120),which was much more higher than that of the normal subjects (21. 43% ) (P<0.05).The positive rate of HLA-B46 in patients with single DU and lesser curvature DU was 52.54% (31/59) (P<0.01) and 61. 11% (11/18) (P<0.05)respectively.HLA - A9 was not found in all of 30 patients with greater curvature DU (P<0.05). Our results indicated that there was a close association between HLA-B46 and DU of Han Nationality in Guangzhou and varied greatly with different races,areas and groups of patients. So HLA is not a real physiological index to overvalue the genetic heterogenicity of peptic ulcer.
出处
《广州医学院学报》
1995年第4期36-38,共3页
Academic Journal of Guangzhou Medical College
