摘要
本文研究了头孢噻甲羧肟在治疗老年医院获得性肺炎的药代动力学及支气管渗透性。结果显示：静滴１ｇ后的血清峰浓度为４７．３４±１．７６ｍｇ／Ｌ，消除半衰期为３．７２±０．５７ｈ，该药能迅速在气道内达到有效抗菌浓度，达峰时间为１～２ｈ，支气管分泌物中峰浓度为５．７７±０．９９ｍｇ／Ｌ，１２ｈ后的维持浓度为４．４３±０．３９ｍｇ／Ｌ，仍大于多数致病菌的ＭＩＣ，预期临床可取得较好疗效。该药的支气管渗透率为８．１～２３．５％。由于该药在老年人体内的代谢和排泄较慢，应注意防止蓄积中毒。
The pharmnacokinetics and bronchial penetration of ceftazidime(CAZ)in five agedpneumonic patients were studied.The results showed that:after intravenous infusion in dose of lg CAZ.the serum peak concentration was 47.34±1.76mg / L,the elimination half-life was 3.72 ±0.57h,the ap-pearance of CAZ in bronchial secretions was rapid,the time to peak concentration was 1～2h,the peakconcentration was 5.77 ±0.99mg / L and remained 4.43 ±0.39mg / L within 12h which was higher thanMIC for most pathogenic bacteria,this ensures its effectiveness in the treatment of aged pneumonia caused by sensitive bacteria,The rate of diffusion of CAZ into bronchial secretions was 8.1～23.5%. The metobolism and excretion for aged patients were slower,so care should be taken of accumulation oxicity.
出处
《中华医院感染学杂志》
CAS
CSCD
1995年第2期68-70,共3页
Chinese Journal of Nosocomiology
