摘要
88例幽门螺杆菌(Hp)感染的卜:指肠溃疡(DU)和功能性消化不良患耆分两期研究.接受7天克拉霉素合并的j联治疗。I期乃预研究,28例随饥分婀组接受电托堪索500mg、呋喃畔刚200mg合}}I}变体次枸橼酸铋(CBS)240mg(A组)或、!索托哗30mg(B组)。¨?次治疗。60例进入ll;《Ij研究符心分AfllB同组.药物配合方棠M I期.似除CBS外.接他药物刊毓i或、{i l、I】彬j—IJ舒BlJ仃4例科】1例Iq约物驯f互『-?术。t限:i^_j’.火i方2例i^泶!Il!_,Ji.I垮jA、BiH f10H1)根除半分SIj为100~;i,(12,12)f1 J91.6‘％(11 12):Il㈣A,B纠i n0Hp橄除?}行}jl_乃92 6‘j;,(25,一’27)和90.0％(27,30)备组问的Hp撤除?爷无!It并蓐别(P】0.0j)。I、ll期·l,削J三J-t j幸j,,别乃64.2,}2,(18j28)和Ij】”i(3/58)(P【0.001)。lI期A、B两组的DU愈合率分别为94.4％(17/18)和100％(18/18)。lJ期r}·的两种低制m地程j联{j’}J、地较乃圳魁的Hp橄除玎案.7.5％(4/j3)的Hp曲株则电十￡。《豢味发耐药.足i青。
To evaluate the effect of short-term low dose triple therapies with clarithromycin(Cla). furazolidone (Fur) together with lansoprazole (Lan) or colloidal bismuth subcitrate (CBS) on the eradication of H. pylori (Hp) infection. Methods: In phase I study 28 patients with duodenal ulcer (DU) or functional dyspepsia (FD) infected with Hp detected by culture and histology received 1-week triple therapy with Cla 500mg bid. Fur 200mg bid together with CBS 240mg bid (Group 1A) or Lan 30mg bid (Group IB). In phase 2 study 60 patients with Hp associated DU or FD were treated with low dose 1-week triple therapy, Cla 250mg bid. Fur 100mg bid and Lan 30mg qd (Group 2A) or CBS 240mg bid (Group 2B). Results: Five patients (2 in Group 1A. 2 in Group 1B. and 1 in group 2A) were withdrawn bacause of side-effects and 2 (Group 2A) were drop out. The eradication rates of Hp in Group 1A. 1B, 2A, and 2B were 100% (12/12), 91.6% (11/12), 92.6% (25/27), and 90.0%y (27/30), respectively. There was no significant difference in the eradication rates between the treatment groups. (P>0.05). In DU the ulcer healing rates in Group 2A, and 2B were 94.4% (17/18) and 100% (18/18). The primary resistance of Hp strains to Cla was 7.5% (4/53). The side-effects were nausea, vomiting and taste disturbance in phase 1 study, but much less in phase 2 study (P< 0.001). Conclusion: One-week, low dose triple therapies with Cla, Fur together with Lan or CBS are highly effective for ulcer healing and eradication of Hp. and are well tolerated. The primary resistance of Hp strains to Cla is the main cause of treatment failure.
出处
《胃肠病学》
1996年第1期11-13,22,共4页
Chinese Journal of Gastroenterology
