摘要
为估计抗精神病药恶性综合征（ＮＭＳ）的发生率，探讨ＮＭＳ发生的原因、临床特征、治疗及预后情况，采用回顾性临床分析方法并根据Ｐｏｐｅ等及Ｌｅｖｅｎｓｏｎ等提出的ＮＭＳ的诊断标准进行确定诊断。结果显示，在我院１９８０～１９９３期间３１７４６例用抗精神病药的住院病人有４０例发生ＮＭＳ，发生率为０．１３％，其中男２８例（７０．０％），女１２例（３０．０％），平均年龄为３２．０±１０．４岁。平均用药剂量为９８４±６２１ｍｇ／日（折合氯丙嗪剂量），合并用药３１例（７７．５％），单一用药９例（２２．５％）。合并用药组使用长效制剂２２例（７１．０％），氟哌啶醇１２例（３９．０％）。单一用药组使用氟哌啶醇５例。共死亡８例，死亡率为２０．０％。这提示ＮＭＳ发生率明显低于所知的国外报道。本征多见于青年男性，尤其是合并用药、使用氟哌啶醇及长效制剂更易发生ＮＭＳ。个体因素也是发生ＮＭＳ的危险因素之一。
Theauthorsestimatedtheincidenceofneurolepticmalifnantsyndrome(NMS)andmadeaclinicalanalysisoftheetiology,clinicalfeatures,clinicalfeatures,treatments,andprophylaxisoftheir40casesofNMS.Inthisretrospectivestudy,althepatientswerestrictlydiagnosedaccordingtooperationalNMSdi-agnosticcriteriaintiatedbyPopeetalandLevensonetal.Amongthe31746in-patientsduringtheperiodof1980～1993,40ofthemdevelopedNMSandthemeanagewas30.0±10.4years.Therewere28males(70.0%)and12females(30%).Theaveragedosagewas984±621mg/dintermsofcholrpromazinedoses.31patientsreceivedcombiabtiontherapyandtheogher9receivedsingledrugtherapy.Inthecombinationtherapygroup,22patients(71%)weregivenagentswithlong-termactionand12patients(39.0%)tookhaloperidol.Inthesingledrugtherapygroup,5patientstookhaloperidol.8patientsinthisseriesdiedandthemortalityratewas20.0%.TheauthorsweretheopinionthatoftheincidenceofNMSreportedinthisarticlewassignificantlylowerthanthoseintheknownreprotsaborad.Youngmalesseemedtobemorelikelytode-velopthissyndrome,especialyinthosewhoreceivedcombinationtherapy,haloperidolandagentswidelong-termactionagents.Someundafinedindividualfactormightbeoneoftheriskfactors.EarlydiagnosisandearlygeneraltreatmentmightbeofbenefitfortherecoveryofNMS.
出处
《中华精神科杂志》
CAS
CSCD
1996年第3期31-34,共4页
Chinese Journal of Psychiatry
