摘要
AIM To study the pathogenetic effect of salted pork (SP) (special food in Zhuanghe City, a high risk area of stomach cancer in northern China) on stomach cancer, and provide scientific basis for primary prevention of stomach cancer in this high risk area. METHODS The study consisted of three parts. The first part was to study the mutagenicity of SP. The Ames test and micro nuclei assay of V 79 cell were employed in this part. The second part was to study the effect of SP on the gastric mucosa of residents in Zhuanghe area who had consumed SP for more than 10 years and the dose effect relations between SP and pathological changes of gastric mucosa. A total of 300 cases were analysed. The third part was to study the mucosal lesions of experimental dogs by gastroscopy and mucosal biopsy. Six healthy male dogs were chosen, three were fed with SP, and the others served as control. RESULTS In this study, the results showed that the extract of SP could lead to mutation of Salmonella typhimurium TA 98 and induce the increase of micro nuclei rate (MNR) and micro nuclei cell rate (MNCR) of V 79 at a dose range of 20～80μl/ml. There were dose effect relations between SP, MNR, MNCR. Pathological changes of gastric mucosa of local residents who had consumed SP showed significant difference from those of the control group. In people who had consumed SP for 10 years, mucosal lesions including necrosis and erosion were found; in those who consumed SP for 10～20 years, hyperplasia and dysplasia were also seen besides the above lesions and those for 20～30 years, severe dysplasia and even malignant changes could be observed. SP had damaging effect on the gastric mucosa of dogs fed with SP. The mucosal lesions became more severe with increasing feeding time. CONCLUSION SP is a strong mutagen and long term exposure to SP may result in repeated gastric mucosal damage and repair, and finally leading to severe dysplasia and malignancy.
ＳｔｕｄｙｏｎｔｈｅｐａｔｈｏｇｅｎｅｔｉｃｅｆｅｃｔｏｆｓａｌｔｅｄｐｏｒｋｆｒｏｍａｈｉｇｈｒｉｓｋａｒｅａｏｆｓｔｏｍａｃｈｃａｎｃｅｒｉｎＣｈｉｎａＹＵＡＮＹｕａｎ１，ＬＩＮＨｕｉＺｈｉ１，ＺＨＡＮＧＹｉｎＣｈａｎｇ１，ＷＡＮＧＸｕａｎ...
