摘要
目的:探讨急性白血病患者凝血因子Ⅷ和Ⅸ的活性变化。方法:采用ACL-200型血凝自动分析仪,测定了20例化疗后急性白血病患者新鲜血浆中凝血因子Ⅷ和Ⅸ活性水平。结果:患者因子Ⅷ和Ⅸ活性水平明显高于正常对照(P<0.05),与化疗疗效无关(P>0.05),其升高程度在M_3中最高,其次是ALL(P<0.05),而在M_5中与对照组相比无明显差异。结论:化疗后急性白血病患者因子Ⅷ和Ⅸ活性水平明显高于正常人,可能与患者体内纤溶亢进引起的代偿性反应有关。
Purpose:To investigate the changes of coagulation factors Ⅷ andⅨactivities in acute leukemia pa-dents. Methods: The coagulation factors ⅧandⅨ activities in 20 post-chemtherapy acute leukemia patients were detected freshly with ACL- 200 Automated Coagulation Laboratory Analyzer. Results: Patients had significantly higher levels of coagulation factors Ⅷand Ⅸ than normal controls, esp in M3 and ALL, but no obvious changes were found in M5 subtype. No correlation were found between the ⅧorⅨ activities and the effects of chemothrapy. Conclusion: The increase of factors Ⅷand Ⅸactivities in post-chemotherapy acute leukemia patients might be related to the compensative reactions caused by hyperfibrinolysis in vitro.
出处
《血栓与止血学》
1997年第4期158-159,共2页
Chinese Journal of Thrombosis and Hemostasis
关键词
急性白血病
凝血因子
acute leukemia, coaguktion factor
