摘要
目的:观察三维适形放疗(3DCRT)同期含铂方案化疗治疗不能手术的III期非小细胞肺癌(NSCLC)的疗效、不良反应及生存期。方法:61例III期NSCLC患者31例给予3DCRT同步含铂方案化疗(适形组),30例给予常规放疗(CRT)同步含铂方案化疗(常规组)。两组均采用以铂类为基础的化疗方案先诱导化疗2周期,2周后分别给予3DCRT或CRT。放疗均采用常规分割,总剂量66GY/33F。放疗期间再按期化疗2个周期。结果:两组总有效率分别为87.1%及63.3%,(P<0.05);中位总生存期分别为17个月和14.5月;1、2年局控率分别为77.4%、53.3%和54.8%、29.0%(P<0.05);1年、2年生存率分别70.9%、46.7%(P>0.05)和45.2%、20.0%(P<0.05)。结论:3DCRT同期含铂方案化疗治疗III期NSCLC与常规放疗同步含铂方案化疗相比,能提高有效率和生存率,且放疗相关性不良反应较常规组低。
Objective：To observe the curative effects,side effects and survival time of conventional radiotherapy（CRT）and three dimensional conformal radiotherapy（3DCRT） concurrently combined with chemotherapy for inoperable stage Ⅲ non-small cell lung cancer（NSCLC）.Methods： Sixty one patients with stage Ⅲ NSCLC were randomized into two groups： 31 patients received 3DCRT concurrently combined with chemotherapy as the conformal group and 30 patients treated with CRT concurrently combined with chemotherapy as the conventional group.Patients in two groups were treated with inductive Cisplatin basement chemotherapy for two cycles and followed by 3DCRT or CRT.For radiotherapy,we all applied conventional fractionation method and a total dose was 66Gy/33F.the patients was given chemotherapy for two cycles during radiotherapy.Results： The total short-term effective rates in the conformal group and conventional group were 87.1% and 63.3%（P0.05）;the median overall survival time was 17 months and 14.5months;1-year and 2-year local control rates were 77.4%,53.3%（P0.05） and 54.8%,29.0%（P0.05）;1-year and 2-year survival rates were 70.9%,46.7%（P0.05） and 45.2%,20.0%（P0.05）.Conclusion： Compared with the conventiona group,the conformal group might be helpful to improve short-term efficacy and overall survival rates,but the side effect in conformal group is lighter.
出处
《现代肿瘤医学》
CAS
2011年第11期2233-2236,共4页
Journal of Modern Oncology
关键词
非小细胞肺癌
三维适形放疗
化学治疗
同步放化疗
non-small-cell lung cancer
three dimensional conformal radiotherapy
chemotherapy
combination chemoradiotherapy
