摘要
目的：探讨脑梗塞脑动脉内溶栓治疗的疗效、时机以及临床应用价值。方法：对６２例不同发病时期脑梗塞患者采用Ｓｅｌｄｉｎｇｅｒ穿刺法，介入性超选择插管至脑动脉内，用尿激酶（Ｕｒｏｋｉｎａｓｅ，ＵＫ）２５～１００万ＩＵ溶栓治疗，观察闭塞血管再通和神经功能障碍恢复程度。结果：闭塞血管再通率达９１．９％，临床总有效率达８７．１％。发病时间＜６ｈ组基本治愈８０．０％，显效２０．０％；基本治愈、显效、有效、无效在其它各组分别为：６～２４ｈ组３３．４％、３７．５％、２１．９％、６．２％；２４～７２ｈ组１８．２％、２７．３％、２７．３％、２７．２％；３～２１ｄ组０％、５０．０％、２５．０％、２５．０％。发病时间＜６ｈ组的基本治愈率加显效率与其它各组比较Ｐ值均＜０．０５，有显著性差异。结论：脑梗塞患者脑动脉内溶栓治疗是一种非常安全、有效的方法，对急性超早期患者疗效十分显著，对亚急性或慢性患者亦具有一定疗效。患者预后与脑动脉内溶栓治疗开始时间呈负相关。
Purpose:To evaluate the efficacy and clinical benefit of intracerebral thrombolysis on cerebral infarction. Method:62 cases of cerebral infarction in different onset time were treated with interventional superselective intracerebral thrombolysis using urokinase 250,000￣1,000,000 IU.The recanalization degree of occlusive cerebrovascular and the recovery of neurological function were observed.Results:The recanalization rate of occlusive cerebrovascular was 91.9%. The total clinical effective rate was 87.1%.The neurological function recovery rates of cured,obvious effected,improved and failed in <6h、6￣24h、24￣72h and3￣21day groups respectively were 80.0% 20.0%、0、0;33.4%、37.5%、21.9%、6.2%;18.2%、27.3%、27.3%、27.2%;0%、50.0%、25.0%、25.0%.There was significant difference between less than 6h group and the other groups in the cured rate ( P <0.05).Conclusion:There was negative correlation between prognosis of the cerebral infarction and the time from the onset to be treated.The intracerebral thrombolysis for cerebral infacrction was an effective and safe method.
出处
《华夏医学》
1999年第4期6-8,共3页
Acta Medicinae Sinica
关键词
脑梗塞
尿激酶
动脉内溶栓术
介入治疗
cerebral infarction
urokinase
intraarterial thrombolysis
interventional treatment
