摘要
目的 探讨乙型肝炎后肝硬化代偿期与失代偿期患者血清NO、IL-8及TNF-α的意义及其相互关系。方法用比色法及ELSA法检测52例乙肝后肝硬化患者血清NO、IL-8、TNF-α的浓度,其中代偿期患者20例,失代偿期32例。结果 肝硬化患者血清NO、IL-8、TNF-α水平明显升高,失代偿期患者升高尤为显著。结论 检测肝硬化患者血清NO水平可作为判断乙肝后肝硬化病情严重程度的指标。炎性因子IL-8及TNF-α升高是肝硬化病情发展的原因之一。
Objective To explore the significance and their relationship of plasma NO,IL-8 and TNF-a in patients with compensated cirrhosis and decompensated cirrhosis after hepatitis B. Methods we detected plasma NO, IL-8 and TNF-a in 52 patients with liver cirrhosis after hepatitis B by colorimetric and ELISA method. Among them, there were 20 compensated cases and 32 decompensated cases. Results The levels of NO, IL-8 and TNF-a were enhanced in patients with liver cirrhosis and the result of decompensated cases showed statistic significance. Conclusion Detection of plasma NO may serve as a guide in decision of the progress of liver cirrhosis after hepatitis B. The enhancement of inflammatory factors IL-8 and TNF-a was one reason in the progress of liver cirrhosis.
出处
《青岛医药卫生》
2000年第1期10-11,共2页
Qingdao Medical Journal
