摘要
目的 了解冠心病病人血浆6种神经肽(6NP),即神经肽Y(NPY)、降钙素基因相关肽(CGPR)、P物质(SP)、脑啡肽(ENK)、神经降压肽(NT)及血管活性肠肽(VIP)的含量,探讨其在冠心病发病中的临床意义。方法 选择符合WHO诊断标准的急性心肌梗死(AMI)20例,心绞痛(AP)30例,应用放射免疫法动态观察血浆6NP的含量变化,并以30例正常人作对照。结果 AMI组发病第1天6NP与对照组比较差异非常显著(P<0.01),第7、14、21天与第1天比较差异非常显著(P<0.05、P<0.01);AP组于心绞痛发作期6NP的含量与对照组比较差异非常显著(P<0.01)。经治疗2周症状缓解后复查血浆6NP含量皆有不同程度的下降和/或上升,前后比较有极显著性差异(P<0.01)。结论 血浆6NP的水平与冠心病的严重程度密切相关;6NP均参与了冠心病的病理生理过程。
Objective To study the clinical meaning of plasma 6 kinds neuropcptide(6NP): NPY,CGRP SP,ENK,NT and VIP levels in patients with coronary heart disease(CHD). Methods The changes of palsma 6NP levels observed by RLA method in 20 patients with acute myocardial infarction( AMI) and 30 patients with angina pectoris( AP) according to the diagnosis criteria WHO. The control group included 30 health persons. Results Cam-pared with normal control group,the levsls of 6NP were different significantly during the 1st day after AMI(P<0. 01). The levels of 6NP during the 7th,l4th and 21th day after AMI were also different significaltly compared with those in the 1st day after AMI(P<0.05, P<0. 01). The 6NP levels in AP group during attack were also different significartly campared with normal control group(P< 0.01) after treatment. For 2 weeks and symptoms relieved, the 6NP levels increased or dicreased significantly(P<0.01) .Conclusion The 6 kinds of 6NP mighe play a role in pathophysio-Iogical and pathogcnetic mechanism of CHD. The severity of the CHD was closely correlated with the 6NP levels.
出处
《中国临床保健杂志》
CAS
2000年第2期60-62,共3页
Chinese Journal of Clinical Healthcare
关键词
急性心肌梗死
心绞痛
神经肽Y
降钙素基因相关肽
P物质
脑啡肽
神经降压肽
血管活性肠肽
Acute myocardial infarction Angina pectoris Neuropeptide Y Calcitonin gene-related pep- tide Substance P Enkephalin Neurotensin Vasoactive intestinal peptide
