摘要
目的:本文探讨心脑欣治疗心绞痛能否产生耐药性问题。方法:分A、B两组,每组20例,治疗8周,A组服用心脑欣1.0gBid,B组服用消心痛10mgdd,每周观察疗效变化。结果:在2周内两组疗效无关异(P>0.05),4至6周时,A组疗效保持平稳,B组则逐渐下降,两组相比P<0.05。8周A组疗效为95%,B组降为655。A组明显优于B组p<0.01,心电图A组为80%,B组只为50%,两组差异性非常显著P<0.01。表明心脑欣长期服用,疗效稳定,不易产生耐药性。
Objective To explore whether Xinnaoxin can cause drug tolerance when the course of treating angina cordis.Methods 40 patients were divided into two groups,group A and group B,20 patients for each group treated for 8 weeks.Xinnaoxin was used in group A in a dosage of 1.0*2/day and Isosorbide dinitrate in group B lOmg*3/day.Re-salts There haven't been showed any difference in the two groups within two weeks.The curative effect was main-tamed steady in group A and declined gradually in group B (P<0.05).The curative effect in group A was 95%and 65% in group B within 8 weeks (P<0.01).The improvement rate of ECG was 80% in group A and 50% in group B.There were significant difference between the two groups(P<0,01).Conclusion It is indicated that the long-term of Xinnaoxin administration have the advantages of stable efficacy and not prone to produce drug tolerance.
出处
《北方药学》
2006年第3期36-37,43,共3页
Journal of North Pharmacy
关键词
心脑欣
心绞痛
耐药性
Xinnaoxin Isosorbide dinitrate Angina cordis Drug tolerance
