摘要
目的观察比较辛温归肺经(豆蔻、紫苏叶、白芷)与辛凉归肺经(薄荷、菊花、前胡)中药对复合因素致肺阳虚大鼠的影响。方法采用烟熏(外邪犯肺)+冰水游泳(形寒劳倦)+服用冰水(内饮生冷)三因素复合造成肺阳虚大鼠模型。造模同时灌胃给予豆蔻、紫苏叶、白芷、薄荷、菊花、前胡水提取物,连续38 d。观察大鼠一般行为学,测量体重、肛温、背温、抓力;末次给药后气管插管毛细玻管法测定排痰量;取血测定血清NO、血液学及血液流变学指标;解剖取心、肺、肝、肾、脾,测脏器系数。结果①辛温归肺经的豆蔻、紫苏叶及白芷能提高肺阳虚大鼠体重、肛温、背温、抓力、血白细胞水平,减少痰量、血清NO、血液黏度、心系数、肺系数、脾系数、肾系数,说明豆蔻、紫苏叶及白芷性味归经相同(同属辛温归肺经),表现出相近的药理作用,通过辛温入肺从而改善形体消瘦、阳虚内寒、背畏寒、体倦乏力、痰涎清稀、肺血亏虚及瘀滞等。②辛凉归肺经的薄荷、菊花及前胡能提高体重、血白细胞水平,降低肝系数;薄荷、前胡还能减少痰量、血液黏度,说明薄荷、菊花及前胡同属辛凉归肺经,也表现出相近的药理作用,通过辛入肺而改善形体消瘦、肺血亏虚及瘀滞、痰涎清稀等。但因其性凉,对肺阳虚证之阳虚内寒、背畏寒等的改善作用不明显。结论性味归经相同的中药表现出相近或相同的药理作用;辛温归肺经、辛凉归肺经中药虽然味辛、作用部位在肺经,但因其性不同,药理作用仍有较大差异。该研究证明了相同味归经中药之间的药效相近,而相同味归经不同性的中药则相关指标作用相反。
Objective To compare the effect of pungent-warm and pungent-cool Chinese herbal medicines with meridian tropism in lung on lung-yang deficiency rats model induced by composite factors.Methods Lung-yang deficiency rat model was established with a three-factor combination method of smoking treatment,swimming in iced water,and oral administration of iced water.Rats in different groups were separately given water extract of the pungent-warm herbs of Fructus Amomi Rotundus,Folium Perillae and Radix Angelicae Dahuricae,and pungent-cool herbs of Herba Menthae,Flos Chrysanthemi and Radix Peucedani by oral administration for 38 continuous days.During the experiment,the general behaviour,body weight,rectal temperature,back temperature,grip strength of rats were observed.After the last administration,the rats were anesthetized and intubated intratracheally with capillary glass tube for measuring the amount of phlegm.Blood samples were collected to estimate the levels of serum nitric oxide（NO）,haematological and hemorheological parameters.Organ tissues such as the lungs,heart,liver,spleen,kidneys were obtained to assess their organ coefficients.Results（1）Pungent-warm Chinese herbal medicines with meridian tropism in lung： The extracts of Fructus Amomi Rotundus,Folium Perillae and Radix Angelicae Dahuricae could increase the decreased body weight,rectal temperature,back temperature,grip strength,white blood cells in model rats.They could also decrease the amount of phlegm,serum NO level,blood viscosity,heart index,lung index,spleen index,and kidney index.It indicated that these three herbs had the same nature,flavor and meridian tropism,so they showed similar pharmacological effects on relieving emaciation,internal cold induced by yang-deficiency,aversion to cold,fatigue,thin phlegm,blood-deficiency and blood stagnation.（2）Pungent-cool Chinese herbal medicines with meridian tropism in lung： The extracts of Herba Menthae,Flos Chrysanthemi and Radix Peucedani could increase the decreased body weight and the amou
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2011年第6期581-586,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家重点基础研究发展计划(973计划
2007CB512603)
关键词
豆蔻
紫苏叶
白芷
薄荷
菊花
前胡
肺阳虚
大鼠
Fructus Amomi Rotundus
Folium Perillae
Radix Angelicae Dahuricae
Herba Menthae
Flos Chrysanthemi
Radix Peucedani
Lung-yang deficiency
Rats
