摘要
目的:评价疏血通注射液治疗急性脑梗死的有效性和安全性。方法:计算机检索Cochrane图书馆、Pubmed数据库、Embase数据库、ISI数据库、CBM数据库、CNKI数据库、VIP数据库、万方数据库,纳入有关疏血通注射液治疗脑梗死的随机对照试验(RCT)、系统评价(SR)和Meta分析。参考纳入的系统评价和Meta分析结论,对纳入的随机对照试验进行方法学质量评价,并采用RevMan5.0软件进行统计分析。结果:共纳入10个RCT。疏血通注射液相对于对照有效药物,其总体有效率差异有统计学意义[RR1.17,95%CI(1.11,1.24)],P<0.01;显效率差异有统计学意义[RR1.49,95%CI(1.18,1.87)],P=0.000 8。神经功能缺损评分经亚组分析,其中3组对照为复方丹参注射液组,其差异有统计学意义[MD=-4.96,95%CI(-6.80,-3.12)],P<0.01;一组对照为葛根素注射液组,其差异有统计学意义[MD=-4.49,95%CI(-7.19,-1.79)],P=0.001;一组对照为低分子肝素注射液,其差异无统计学意义(P=0.36)。纳入的研究未报道相关严重不良反应。结论:基于当前证据,疏血通注射液治疗急性脑梗死疗效较好,不良反应少,是治疗急性脑梗死安全有效的中成药。
OBJECrlVE To assess the effectiveness and safety of Shuexuetong-injection in treatment of acute cerebral infarction. METHODS Both the English and the Chinese studies involving randomized controlled trials（RCTs）, systematic review （SR） and meta analysis were collected from the database, such as the Cochrane Library, Pubmed, Embase, ISI, CBMdise, CNKI, VIP and Wanfang database from the year they founded to 2009. After the necessary methodological quality evaluation of the selected studies,the statistic analysis was conducted with the software RevMan 5.0. RESULTS Ten RCTs were included. The difference of the total effective rate between Shuexuetong-injection groups and the control groups was statistically significant [RR 1.17,95 % CI （ 1.11, 1.24） ], P〈 0. 01 ; and so it was with the significant rate [RR 1.49, 95 % CI （ 1.18, 1.87） ], P = 0. 000 8. Since the heterogeneity on neurological impairment score is too high, these trials were divided into three subgroups according to the control drugs. The control drugs of three trials were compound Danshen injection, and the difference of the neuro- logical impairment score between Shuexuetong-injection groups and the control groups was statistically significant[MD -4. 96, 95%CI（ -6. 80, -3. 12）], P〈0. 01. One control drug was compound puerarin injection, and the difference of the neurological impairment score between Shuexuetong-injection groups and the control groups was statistically significant[MD - 4. 49,95 %CI （ - 7. 19, - 1.79）], P =0. 001. The other was low-molecular-weight heparins calcium injection and they had no difference in statistics （P = 0. 36）. The involved trials didn＇t have serious ADR. CONCLUSION Current evidences show Shuexuetong-injection is effective and safe in treating acute cerebral infarction.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第22期1846-1850,共5页
Chinese Journal of Hospital Pharmacy
基金
国家"十一五"科技支撑计划重点项目"基层医疗机构主要基本药物合理使用评价和研究"课题(编号:2009BAI76B03)
关键词
疏血通注射液
脑梗死
缺血性脑卒中
系统评价
Shuexuetong injection
cerebral infarction
ischemic stroke
systematic review
