摘要
目的:探讨依折麦布对轻度血脂异常的原发性高血压患者肱动脉内皮依赖性扩张功能(FMD)及尿微量白蛋白的影响。方法:入选原发性高血压患者85例,随机分为依折麦布组(46例)和对照组(39例),治疗随防8个月。治疗前及后行血脂水平、肱动脉内皮依赖性扩张功能(FMD)和尿白蛋白/肌酐等检查。结果:以上两组患者基线情况相似。依折麦布组患者用依折麦布等治疗8个月后,总胆固醇、LDL胆固醇及尿白蛋白/肌酐均有显著下降;依折麦布组患者治疗8个月后负荷后1 h的FMD升高最大,明显高于对照组患者治疗8个月后后负荷后1 h的FMD,依折麦布组患者治疗8个月后负荷后4 h的FMD升高也较大,明显高于对照组患者治疗8个月后负荷后4 h的FMD。结论:常规降压药物基础上加用新型降脂药物依折麦布能明显改善轻度血脂异常的原发性高血压患者肱动脉FMD及稳定或逆转动脉粥样硬化的进展。
Objective To explore the effects of ezetimide on endothelium dependent flow-mediated vasodilation （FMD） in arteria brachialis and microalbumin in urine in patients with essential hypertension and mild dyslipidemia. Methods A total of 85 patients with essential hypertension were randomly assigned to conventional anti-hypertensive drugs plus ezetimide group （ezetimide group, n = 46） and conventional anti-hypertensive drugs group （conventional group,n = 39）.All the patients were treated and followed-up for 8 months. The changes of cholesterol in blood, microalbumin and creatinine in urine, and FMD were analyzed. Results At the end of 8 months, levels of total cholesterol and LDL-C in blood, and the ratio of microalbumin/creatinine were decreased significantly in ezetimide group, and FMD at 1 and 4 hour were significantly higher in ezetimide group than those in conventional group. Conclusion Ezetimide plus conventional anti-hypertensive drugs treatment yielded better results in the context of improving FMD and showed favorable effects on arteriosclerosis in patients ~ith hypertention and mild dyslipidemia.
出处
《实用医学杂志》
CAS
北大核心
2011年第22期4127-4129,共3页
The Journal of Practical Medicine
关键词
高血压
动脉粥样硬化
血管
内皮
依折麦布
Hypertension
Arteriosclerosis
Endothelium, vascular
Ezetimide
