摘要
目的:探讨持续低效缓慢血液透析在终末期糖尿病肾病患者维持性血液透析中的血流动力学稳定性及溶质的清除效果。方法:选择维持性血液透析的终末期糖尿病肾病患者30例,按二阶段设计,比较持续低效缓慢血液透析与普通血液透析两种治疗中低血压的发生率和溶质的清除情况。结果:持续低效缓慢血液透析与普通血液透析两种治疗中低血压的发生率分别为6.7%和18.9%,差异有统计学意义(P=0.014);两种治疗均能有效清除K、BUN、PO4及β_2-MG,治疗前后差异有统计学意义;持续低效缓慢血液透析较普通血液透析较好地清除BUN、PO4及β_2-MG,差异具有统计学意义(P=0.020,P=0.001,P=0.010),但两种治疗对白蛋白的影响的差异不具有统计学意义。结论:持续低效缓慢血液透析在终末期糖尿病肾病患者中具有较为稳定的血流动力学特点和较好的中小分子毒素的清除率,可以改善患者的透析依从性和生存质量。
Objectives To evaluate the hemodynamic stability during the curing session and the effect of solute removal with sustained low efficiency hemodialysis in patients with end-stage diabetic nephropathy. Methods Thirty patients with end-stage diabetic nephropathy receiving maintenance hemodialysis were selected in the study and cmnpared by the occurrence of hypotension during the curing session and the effect of solute removal between sustained low efficiency hemodialysis and conventional hemodialysis with Two-stage trials. Results The rate of hypotension of the patients was 6.7% during sustained low efficiency hemodialysis and 18.9% during conventional hemodialysis.The difference of the rate of intradialytic hypotension between them was statistically significant.The K, BUN, PO4 and β2-MG could be effectively removed with both treatments.The difference between before and after treatment was statistically significant.The BUN, PO4 and β2-MG were more effectively removed with sustained low efficiency hemodialysis than with conventional hemodialysis.The difference between them was statistically significant.But the difference of the changes of albumin between sustained low efficiency hemodialysis and conventional hemodialysis was not statistically significant. Conclusion Sustained low efficiency hemodialysis perform stable hemodynamic characteristic and better small molecular toxins removal in patients with end-stage diabetic nephropathy.h may improve compliance of dialysis and quality of life for the patients.
出处
《实用医学杂志》
CAS
北大核心
2011年第22期4005-4007,共3页
The Journal of Practical Medicine
