摘要
分离九里香叶中具有抗炎镇痛活性的香豆素类化合物。利用小鼠扭体镇痛实验为活性跟踪动物模型,以硅胶色谱柱为分离手段,以波谱学为空间鉴定手段,并以小鼠扭体镇痛实验和二甲苯致耳朵肿胀实验为活性鉴定的动物模型。分离得到了6种香豆素类化合物,分别为蛇床子素、脱水长叶九里香内酯、橙皮内酯、伞形花内酯、东莨菪素、Murracarpin。药理学活性研究发现Murracarpin的抗炎镇痛活性最强。Murracarpin具有强抗炎镇痛活性,可能与其C-7位上的甲氧基,C-8位上的一个短的支链且都含有双键及醇羟基等结构有关。
The coumarins compounds that possed anti-inflammation and analgesic acitivities were separated from Murraya exotica（L.）.Using mice writhing test as animal model of activity trace,silica gel chromatographic column as separation means,spectroscopy as the ways to determine the structures,and mice writhing test and xylene-induced ear edema test were employed to determine the anti-inflammation and analgesic activities.Six coumarins compounds were obtained.They were osthole,phebalosin,meranzin,umbelliferone,scopoletin,and murracarpin.Murracarpin exhibited strong anti-inflammatory and analgesic activity,which possibly related to its structure including a methoxy group at C-7,a short chain at C-8 which contained both double-bond and hydroxyl groups.
出处
《光谱实验室》
CAS
CSCD
北大核心
2011年第6期2999-3003,共5页
Chinese Journal of Spectroscopy Laboratory
