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常染色体显性多囊肾一家系男性患者AZF微缺失研究 被引量：2

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摘要 目的通过对一常染色体显性多囊肾家系男性患者进行AZF微缺失检测,了解其AZF基因缺失情况及不育原因。方法用聚合酶链反应技术扩增ADPKD家系男性成员sY84、sY86、sY127、sY134、sY152、sY153、sY254、sY255等8个AZF位点,并以X/Y连锁锌指蛋白基因(ZFX/Y)为内对照。结果家系中1例严重少弱精子症男性患者存在sY254缺失。结论该ADPKD家系男性患者AZF微缺失可能与其精子生成障碍相关。
作者 贾颐舫 杨丹彤 张爱东 盖凌 张美华 张艳萍 许观照 吴爱华 邱毅
机构地区 山东省计划生育科学技术研究所山东省优生技术重点实验室
出处 《中国优生与遗传杂志》 2011年第11期12-13,共2页 Chinese Journal of Birth Health & Heredity
基金 山东省自然科学基金(Q2003C02)
关键词 常染色体显性多囊肾 AZF微缺失 家系
分类号 R692.1 [医药卫生—泌尿科学]
  • 相关文献

参考文献8

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二级参考文献25

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共引文献15

同被引文献42

  • 1熊承良,商学军,刘继红主编.人类精子学.北京:人民卫生出版社,2013.121. 被引量：3
  • 2张新东,金保方.精囊在男性生殖和性功能中的作用[J].中华男科学杂志,2007,13(12):1113-1116. 被引量：7
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引证文献2

二级引证文献8

中国优生与遗传杂志
2011年 第11期

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