摘要
目的了解社区感染菌与医院感染菌的耐药性差异及在细菌耐药预警机制中的影响差异,从而为临床合理使用抗菌药物提供更准确的参考。方法 2010年对微生物室分离菌株感染性质进行区分,比较两类菌的耐药性差异.并以耐药率>75.0%作为合理用药的最高预警机制,比较社区感染菌株与医院感染菌株差异。结果两类感染株排前5位的均为金黄色葡萄球菌、鲍氏不动杆菌、大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌,但排名顺序不同,且两类感染的耐药率差异有统计学意义(P<0.05);其中金黄色葡萄球菌、鲍氏不动杆菌医院感染株对多数抗菌药物的耐药率>75.0%,铜绿假单胞菌的耐药率均<75.0%;以上5种分离菌中除铜绿假单胞菌无明显差异外,其他均存在差异。结论耐药菌监测及治疗过程中应区分不同的感染性质,能更合理使用抗菌药物,减少细菌耐药性的产生。
OBJECTIVE To understand the difference on drug-resistance and the macheanisms between nosocomial infection （NI） and community-acquired infection strains （CI） to provide bases for rational usage antibiotics. METHODS All the isolated bacteria Of nosocomial and community-acquired strains were daily monitored in our hospital in 2010 by the methods of prospective, Top 5 pathogens resistant to antibiotics has been counted. Chi square test was used （P〈0.05）and the resistance rate〉75.0%. As the highest guiding rational use of drugs early warning mechanism compared with nosocomial and community-acquired pathogens. RESULTS Among five strains Staphylococcus aureus, E. coli, K. pneumoniae , A. baumannii and P. aeruginosa isolated from NI patients had higher resistance to most antibacterial agents than those from CI patients. Difference on early warning mechanism of antimicrobial drug （drug-resistance 〉75.0%） except P. aeruginosa. CONCLUSION In order to reduce abuse of antibacterial agents and drug resistance, resistant monitoring and anti-infection treatment should be applied according to infection types.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第21期4556-4558,共3页
Chinese Journal of Nosocomiology
基金
医院科研基金项目(txu1023)
关键词
医院感染
社区感染
抗菌药物
预警机制
耐药性
Nosocomial infection
Community-acquired infection
Antibiotics
Early warning mechanism
Drug resistance
