摘要
目的：比较奥氮平舍并丙戊酸钠治疗双相Ⅰ型障碍急性躁狂发作的疗效及安全性。方法：60例符合DSM～Ⅳ诊断标准的双相Ⅰ型障碍急性蹀狂发作患者随机分为奥氮平合并丙戊酸钠组及单独使用丙戊酸钠组，治疗6周。以Bech—Rafaelsen躁狂量表（BRMS）、临床疗效总评量表（CGI）评估疗效，由副反应量表（TESS）评定治疗中出现的不良反应。结果：奥氮平合并丙戊酸钠组的减分率比单独使用丙戊酸钠组显著，这种差异在6周内一直存在，两组均没有严重的药物不良反应。结论：奥氮平合并丙戊酸钠治疗双相Ⅰ型障碍急性躁狂发作，疗效和不良反应与丙戊酸钠无明显差并，但是起效迅速。
Objective ： To explore efficacy and safety of olanzapine combining valproate in the treatment of patients with Bipolar I disorder acute manic episodes. METHODS Sixty patients meeting the criteria of DSM - IV for Bipolar I disorder acute manic episodes were randomly divided into two groups （ n = 30） ,which was as- signed to receive olanzapine combining valproate or valproate alone for 6 weeks. Clinical efficacy was evaluated with Bech - Rafaelsen mania rating scale （BRMS） and Clinical Global Impression. （CGI）, side effects were evaluated with treatment emergent symptom scale （TESS） and related examinations affiliated to the study. RE- SULTS ： The decreasing rate of BRMS by olanzapine group was significantly higher than that of control group, and this difference sustain for 6 weeks. Both groups have not serious side effects. CONCLUSION ： The effects of olanzapine combined with valproate is better than that of single valproate.
出处
《医学信息（下旬刊）》
2011年第10期112-112,共1页
Medical information
