摘要
目的应用固体分散技术,提高二氢槲皮素及其片剂的体外溶出度。方法以PEG-4000、PEG-6000和PVP-K30为载体,采用溶剂-熔融法制备了二氢槲皮素固体分散体,考察不同载体对固体分散体溶出度的影响。同时制得二氢槲皮素固体分散体片,并着重考察了片剂的体外溶出度。结果以亲水性PVP-K30为载体制备的固体分散体能够显著的提高二氢槲皮素的体外溶出度,制成固体分散片剂后,二氢槲皮素固体分散体片的溶出度可达86.8%。结论以PVP-K30为载体的固体分散体片可提高二氢槲皮素的溶解度,制备二氢槲皮素固体分散片达到设计要求,且制法简便可行。
AIM To improve the dissolution of taxifolin tablet with solid dispersion technology in vitro.METHODS Taxifolin solid dispersion was prepared by dissolvent-fusion method,with PEG-4000,PEG-6000 and PVP-K30 as carriers,to investigate the effects of different carriers on the dissolution of solid dispersions in vitro.And taxifolin solid dispersion tablet was prepared to study the dissolution of the tablets in vitro.RESULTS The dissolution of taxifolin was significantly improved by solid dispersion with hydrophilic PVP-K30 as carrier in vitro,and the dissolution of the taxifolin solid dispersion tablet with this carrier could be 86.8%.CONCLUSION The SDs carried with PVP-K30 is used to increase the solubility of taxifolin.Taxifolin solid dispersing tablet achieves the design requirements,and the preparation method is simple and feasible.
出处
《中成药》
CAS
CSCD
北大核心
2011年第10期1692-1695,共4页
Chinese Traditional Patent Medicine
基金
中俄总理定期会晤政府间科技合作计划项目(CR11-69)
哈尔滨市科技(对俄)攻关计划项目(2006AA3BE055)
