摘要
刚地弓形虫在入侵和寄生于宿主细胞,引起急性与慢性感染的过程中,对宿主细胞进行精细的、整体的调控,在激发和抑制宿主免疫反应之间保持一个精细的平衡,保证弓形虫在宿主细胞内成功地生存增殖,并有机会传播给终末宿主;在此过程中宿主细胞的信号转导发生广泛的应激变化,在弓形虫入侵、寄生过程中及与弓形虫-宿主相互关系中起着重要作用。本文拟从5个方面综述弓形虫感染对宿主细胞信号通路的调控作用:①弓形虫分泌蛋白调控宿主细胞信号转导,②弓形虫调节宿主天然免疫、保护性免疫相关的细胞信号通路,③弓形虫调控与抗凋亡及细胞周期相关的宿主细胞信号转导,④弓形虫调节宿主细胞钙离子信号通路,⑤弓形虫调节与细胞结构重组相关的宿主细胞信号转导。
In the process of invasion and development in host cells,Toxoplasma gondii causes acute and chronic infection.The parasite manipulates the host cell elaborately and integrately to keep a delicate balance between induction and elimanation of the host cell immune reaction.It can then dwell and multiply successfully in the host cell,and hopefully be transmitted to a definitive host.The host cell signaling is changed and regulated extensively by the parasite in the process,which plays vital roles in parasite invasion and development.This review shed light on the manipulation of host cell signaling by T.gondii infection in these aspects：① T.gondii secreted proteins which manipulate host cell signaling;② T.gondii modulates the innate and protective immune related host cell signaling;③ T.gondii regulates anti-apoptotic reaction and cell cycle related host cell signaling;④ T.gondii adjusts calcium relevant host cell signaling;⑤ T.gondii manipulates cell structure reorganization relevant host cell signaling.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2011年第5期378-384,共7页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(No.81071377)
广东省自然科学基金(No.10151051501000033)
高等学校博士学科点专项科研基金(No.20104433120014)
广东省医学科研基金(No.A2010356)
广东省大学生创新实验计划项目(No.1212110047)
南方医科大学院长基金(No.GW201110)~~
关键词
刚地弓形虫
入侵
发育
宿主细胞
细胞信号
Toxoplasma gondii
Invasion
Development
Host cell
Cell signal
