摘要
以对二甲氨基苯甲醛(DMAB)和1,4-二(3-氨基丙基)哌嗪(BAPP)为原料,通过缩合反应合成了一个新的DMAB-BAPP希夫碱。利用正交试验确定了最佳合成工艺条件,即反应温度50℃,反应时间4 h,DMAB与BAPP投料摩尔比是2.1∶1,在此条件下,产物收率为83.7%。通过琼脂扩散法测定了产物的抑菌性能,结果表明,该希夫碱对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌均具有良好的抑菌活性。
A new Schiff base bis（4-dimethylaminobenzaldehyde）-[1,4-bis（3-aminopropyl）piperazine] was synthesized by the condensation reaction of 4-dimethylaminobenzaldehyde and 1,4-bis（3-aminopropyl）-piperazine.The optimal synthetic conditions obtained by orthogonal experiment were as follows： reaction temperature of 50℃,reaction time of 4 h,and the mole ratio 4-dimethylaminobenzaldehyde to 1,4-bis（3-aminopropyl）piperazine of 2.1∶1.The yield of the title product was about 83.7%.The antibacterial activity was investigated by agar diffusion method,and the results indicated that the Schiff base was active against Staphyloccus aureus,Escherichia coli and Bacillus subtilis.
出处
《化学世界》
CAS
CSCD
北大核心
2011年第10期623-625,共3页
Chemical World
基金
江苏省青蓝工程优秀青年骨干教师资助项目(苏教师[2008]16)
