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多杀菌素生物合成途径及改造策略 被引量：9

Biosynthetic pathway and synthetic strategy of spinosad—A review
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摘要 多杀菌素是一类由刺糖多孢菌产生的新型大环内酯类化合物,是绿色农用抗生素的杰出代表。本文简要总结了多杀菌素生物合成过程,并对其生物合成调控的关键位点进行了分析,提出用合成生物学手段组装多杀菌素细胞工厂的策略。 Spinosad is a novel macrolide insecticide produced by Saccharopolyspora spinasa,widely used in agriculture.Here its biosynthetic pathway,and key regulatory nodes were reviewed and analyzed.A synthetic strategy to reprogram spinosad biosynthetic pathway was proposed.
作者 李月 常城 杨克迁
机构地区 兰州大学生命科学学院 中国科学院微生物研究所
出处 《微生物学报》 CAS CSCD 北大核心 2011年第11期1431-1439,共9页 Acta Microbiologica Sinica
基金 国家自然科学基金资助(NSFC30770240)~~
关键词 多杀菌素 刺糖多孢菌 合成途径 代谢调控 合成生物学 spinosad Saccharopolyspora spinosa biosynthetic pathway metabolic regulation analysis synthetic biology
分类号 S482.3 [农业科学—农药学]
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参考文献25

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同被引文献120

  • 1代鹏,徐雪莲,贺玉平,戴经元,林开春.多杀菌素生产菌株发酵配方及条件的优化[J].华中农业大学学报,2006,25(3):245-248. 被引量：12
  • 2沈兆兵,陈国豪,陈长华.豆油在红霉素发酵中的作用及作用机制的研究[J].中国抗生素杂志,2006,31(11):657-660. 被引量：11
  • 3王彦华,王鸣华.多杀菌素的作用机理及其抗药性的研究进展[J].农药科学与管理,2006,27(11):12-15. 被引量：19
  • 4胡旭晔,张琴,胡海峰,朱宝泉.多杀菌素的发酵工艺研究[J].中国医药工业杂志,2007,38(2):90-93. 被引量：5
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  • 7HUANG K X, XIA Li-qiu, ZHANG You-ming, et al. Recent Advances in the Biochemistry of Spinosyns[J]. Applied Microbiology and Biotechnology, 2009, 82(1): 13-23. 被引量：1
  • 8STROBEL R J, NAKATSUKASA W M. Response Surface Methods for Optimizing of Saccharopolyspora spinosa, a Novel Macrolide Producer[J]. Journal of Industrial Microbiology, 1993, 11(2): 121-127. 被引量：1
  • 9RALPH B, DRIK R, REINHARD G. Data and Knowledge Based Experimental Design for Fermentation Process Optimization[J]. Enzyme and Microbial Technology, 2000, 27(10): 784-788. 被引量：1
  • 10黄华江.实用化工计算机模拟:MATLAB在化学工程中的应用[M].2版.北京:化学工业出版社,2010. 被引量：1

引证文献9

二级引证文献28

微生物学报
2011年 第11期

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