摘要
目的:探讨消痈溃得康颗粒对胃溃疡活动期患者幽门螺杆菌的影响,反证"毒热"为胃溃疡活动期的病因,幽门螺杆菌为"毒热"病因要素的生物学基础。方法:选取胃溃疡活动期符合中医胃毒热证患者300例,采用随机对照双盲双模拟试验研究方法,治疗组150例口服消痈溃得康颗粒加溃疡胶囊模拟剂,对照组150例口服溃疡胶囊加消痈溃得康颗粒模拟剂,6周后,采用快速尿素酶法试验测定幽门螺杆菌的根除率及中医症状积分变化,进行统计分析。结果:治疗组脱落8例,对照组脱落6例。治疗前后两组幽门螺杆菌的分级量化评分有统计学差异(P<0.01);胃脘灼痛,痛势较剧,泛酸嘈杂,口干及口苦记分两组治疗前比较,差异均无统计学意义(P>0.05);胃脘灼痛,痛势较剧,泛酸,嘈杂,口干及口苦的改善治疗后两组间记分差异有统计学意义,治疗组优于对照组(P<0.01)。综合疗效:符合方案集(PPS):治疗组临床痊愈率为45.1%(64/142),总有效率为99.3%(141/142);对照组分别为6.9%(10/144),91.0%(131/144),两组比较,差异有统计学意义(P<0.01);全分析集(FAS):治疗组临床痊愈率为42.7%(64/150),总有效率为94.0%(141/150);对照组分别为6.7%(10/150),87.3%(131/150),两组比较,差异有统计学意义(P<0.05)。结论:清热解毒、消痈生肌之消痈溃得康颗粒可以有效根除胃溃疡活动期患者幽门螺杆菌,显著改善中医症状,从而达到治疗胃溃疡的目的,且疗效优于对照组,以效测证,反证了"毒热"确为胃溃疡活动期的重要病因,幽门螺杆菌为"毒热"病因要素的重要生物学基础之一。
Objective：To discuss the ＂poison-heat＂ was the etiopathogenisis of gastric ulcer in active stage and Hp infection were biological substructure of ＂poison -heat＂ through approaching the action of Xiaoyongkuidekang Granule acted on Hp infec- tion in patients with gastric ulcer in active stage. Methods：300 patients with gastric ulcer in active stage were selected with features of gastric poison - heat syndrome in TCM and divided into experiment and control group in double - blind/simulation RCT. 150 patients in experiment group were treated with Xiaoyongkuidekang Granule and Kuiyang simulated capsule;150 patients in control group were treated with Kuiyang capsule and Xiaoyongkuidekang simulated Granule. Hp was tested by t~@d urease method and symptoms integral of TCM collected in 6 weeks were analyzed statistically. Results ： There were g cases loss in experimental group and 6 cases loss in control group. There were significant statistical differences of Hp grade quantizing score before and after treatment in both groups. The experimental group got a better effect than control group in symptoms improving and got a significant statistical difference which P 〈 0.01. Synthetic effect ： PPS ： There were clinical recovery rate 45.1% （64/142） and total effective rate 99.3% （141/142）in experimental group. There were clinical recovery rate 6.9% （10/144） and total effective rate 91.0% （131/144） in control group. There were significant statistical differences and P 〈 0.01 in clinical recovery rate and total effective rate between groups. FAS ：There were elinical recovery rate 42.7 % （64/150）and total effective rate 94.0% （141/150） in experi- mental group. There were clinical recovery rate 6.7% （10/150） and total effective rate 87.3% （131/150） in control group. There were significant statistical differences and P 〈 0.05 in clinical recovery rate and total effective rate between groups. Conclusion ： Xiaoyongkuidekang Granule had got a function with clearing away the he
出处
《辽宁中医杂志》
CAS
北大核心
2011年第11期2218-2221,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)资助项目
关键词
胃溃疡
活动期
毒热
病因创新
幽门螺杆菌
gastric ulcer
in active stage
＂poison - heat＂
etiopathogenisis innovation
H. pylori
