摘要
NK细胞（NKs）是一种固有免疫的效应细胞，它无需抗原预先致敏即可识别肿瘤等异常细胞。在它表面有一类重要的受体KIR（killer immunoglobulin—like receptors）家族，它的配体是HLAI类分子。异体NK细胞是来源于遗传背景不同的两个个体的NK细胞，这种NK细胞在恶性肿瘤的临床治疗中发挥了重要的作用。供受者之间基因型不匹配模式及特殊类型KIR基因型对造血干细胞移植患者预后均有不同的影响。
Natural killer cells （NKs） are lymphocytes of the innate immune system, it could recognize and lyse the tumor without being sensitized by antigens. Killer immunoglobulin-like receptors are the most im- portant receptors on the surface of NKs whose ligands are human leucocyte antigen class I. Allo-geneie NK cells come from different genetic background of donors and reeeiptors which display potential anti-tumor efficiency in clinical treatment of multiple malignancy. The patterns of mismatched genotypes between donors and receiptors included KIR-KIR,KIR-HLA,HLA-HLA and special types of KIR genotype impact the prognosis of patients dif- ferently after hematopoietic stem cell transplantation（HSCT）.
出处
《国际免疫学杂志》
CAS
北大核心
2011年第6期357-360,共4页
International Journal of Immunology
基金
天津市科技创新专项基金项目（06FZZDSF01500）
